Stephen Damato
Royal National Orthopaedic Hospital
6 Papers
Stephen Damato is an academic researcher from Royal National Orthopaedic Hospital. The author has contributed to research in topics: Germline mutation & Ollier disease. The author has an hindex of 4, co-authored 4 publications.
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Papers
IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours
M Fernanda Amary,Krisztian Bacsi,Francesca Maggiani,Stephen Damato,Dina Halai,Fitim Berisha,Robin Pollock,Paul O'Donnell,Anita Grigoriadis,Tim C. Diss,Malihe Eskandarpour,Nadege Presneau,Pancras C.W. Hogendoorn,Andrew Futreal,Roberto Tirabosco,Adrienne M. Flanagan,Adrienne M. Flanagan +16 more
TL;DR: IDH1 and IDH2 mutations represent the first common genetic abnormalities to be identified in conventional central and periosteal cartilaginous tumours and speculate that a mosaic pattern of IDH‐mutation‐bearing cells explains the reports of diverse tumours (gliomas, AML, multiple cartILaginous neoplasms, haemangiomas) occurring in the same patient.
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Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2
M Fernanda Amary,Stephen Damato,Dina Halai,Malihe Eskandarpour,Fitim Berisha,Fiona Bonar,Stan McCarthy,Valeria Fantin,Kimberly Straley,Samira B Lobo,Will Aston,Claire Green,Rosemary E. Gale,Roberto Tirabosco,Andrew Futreal,Peter J. Campbell,Nadege Presneau,Adrienne M. Flanagan,Adrienne M. Flanagan +18 more
TL;DR: It is shown that in 37 of 40 individuals with these syndromes, at least one tumor has a mutation in isocitrate dehydrogenase 1 (IDH1) or in IDH2, 65% of which result in a R132C substitution in the protein.
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The Prognostic Characteristics and Recurrence Patterns of High Grade Endometrioid Endometrial Cancer: A Large Retrospective Analysis of a Tertiary Center
Andreas Zouridis,K. Zarrindej,J. Rencher,S Smyth,Negin Sadeghi,Ali Raza Sattar,Stephen Damato,Federico Ferrari,Antonio Simone Laganà,Mostafa Abdalla,Sean Kehoe,Susan Addley,Hooman Soleymani Majd +12 more
TL;DR: In this paper , the authors evaluated the independent risk factors for recurrence and mortality and described the recurrence patterns of high grade endometrioid endometrial cancer (HGEEC).
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Perivascular epithelioid cell tumour and investigation of genetic susceptibility
TL;DR: In this paper , a patient in her 60s was referred to Gynaecology-oncology for an incidental large uterus with a history of renal cell carcinoma and melanoma, and she underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy.
IDH1 mutations are not found in cartilaginous tumours other than central and periosteal chondrosarcomas and enchondromas.
Stephen Damato,Mohammed Alorjani,Fiona Bonar,Stanley W. McCarthy,Stephen R. Cannon,Paul O'Donnell,Roberto Tirabosco,M Fernanda Amary,Adrienne M. Flanagan +8 more
TL;DR: Napsin A expression in SH seems to further support the most recent and accepted hypothesis that this benign and polymorphic pulmonary tumour differentiates towards the peripheral respiratory epithelium.