Stephen Blackmore
Beth Israel Deaconess Medical Center
7 Papers
12 Citations
Stephen Blackmore is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Immune system & Viremia. The author has an hindex of 5, co-authored 7 publications.
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Papers
Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys
James B. Whitney,Alison L. Hill,Srisowmya Sanisetty,Pablo Penaloza-MacMaster,Jinyan Liu,Mayuri Shetty,Lily Parenteau,Crystal Cabral,Jennifer L. Shields,Stephen Blackmore,Jeffrey Y. Smith,Amanda L. Brinkman,Lauren Peter,Sheeba I. Mathew,Kaitlin M. Smith,Erica N. Borducchi,Daniel I. S. Rosenbloom,Mark G. Lewis,Jillian Hattersley,Bei Li,Joseph Hesselgesser,Romas Geleziunas,Merlin L. Robb,Jerome H. Kim,Nelson L. Michael,Dan H. Barouch +25 more
TL;DR: It is demonstrated that the viral reservoir is seeded rapidly after intrarectal SIV infection of rhesus monkeys, during the ‘eclipse’ phase, and before detectable viraemia, which raises important new challenges for HIV-1 eradication strategies.
Construction and Evaluation of Novel Rhesus Monkey Adenovirus Vaccine Vectors
Peter Abbink,Lori F. Maxfield,David Ng’ang’a,Erica N. Borducchi,M. Justin Iampietro,Christine A. Bricault,Jeffrey E. Teigler,Stephen Blackmore,Lily Parenteau,Kshitij Wagh,Scott A. Handley,Guoyan Zhao,Herbert W. Virgin,Bette T. Korber,Dan H. Barouch,Dan H. Barouch +15 more
TL;DR: The primary isolation and vectorization of three novel adenoviruses from rhesus monkeys are described, representing a new class of candidate vaccine vectors that exhibit virologic and immunologic characteristics that make them attractive as potential vaccine vectors for both HIV-1 and other pathogens.
Augmented Replicative Capacity of the Boosting Antigen Improves the Protective Efficacy of Heterologous Prime-Boost Vaccine Regimens
Pablo Penaloza-MacMaster,Jeffrey E. Teigler,Rebecca C. Obeng,Zi H. Kang,Nicholas M. Provine,Lily Parenteau,Stephen Blackmore,Joshua Ra,Erica N. Borducchi,Dan H. Barouch,Dan H. Barouch +10 more
TL;DR: It is suggested that the replicative capacity of the boosting antigen influences the protective efficacy afforded by prime-boost vaccine regimens and a benefit of robustly replicating vaccine vectors is suggested.
11
•Journal Article
Adenovirus 5 vaccination elicits IL-27, which impairs CD4 and CD8 T cell functionality (VAC12P.1113)
Rafael A. Larocca,Nicholas M. Provine,Mark Justin Iampietro,Erica N. Borducchi,Pablo Penaloza-MacMaster,Christine A. Bricault,Eryn Blass,Lily Parenteau,Stephen Blackmore,Kathryn E. Stephenson,Dan H. Barouch,Dan H. Barouch +11 more
TL;DR: The goal is to elucidate the phenotypic differences of the CD4 and CD8 T cell repertoire following Ad5 or Ad26 vaccination and the underlying mechanism.
1
Vaccine-elicited CD4 t cells induce immunopathology after chronic lcmv infection
Pablo Penaloza-MacMaster,Daniel L. Barber,E. John Wherry,Nicholas M. Provine,Jeffrey E. Teigler,Lily Parenteau,Stephen Blackmore,Erica N. Borducchi,Rafael A. Larocca,Kathleen B. Yates,Hao Shen,W. Nicholas Haining,Rami Sommerstein,Daniel D. Pinschewer,Daniel D. Pinschewer,Rafi Ahmed,Dan H. Barouch,Dan H. Barouch +17 more
TL;DR: Results demonstrate that vaccine-elicited CD4 T cells in the absence of effective antiviral immune responses can trigger lethal immunopathology, and may have implications for vaccines against chronic viruses such as HIV.