Stephen A. McCartney
Washington University in St. Louis
13 Papers
294 Citations
Stephen A. McCartney is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: MDA5 & TLR3. The author has an hindex of 10, co-authored 13 publications. Previous affiliations of Stephen A. McCartney include Johns Hopkins University School of Medicine.
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Papers
Activation of an immunoregulatory and antiviral gene expression program in poly(I:C)-transfected human neutrophils.
Nicola Tamassia,Vincent Le Moigne,Marzia Rossato,Marta Donini,Stephen A. McCartney,Federica Calzetti,Marco Colonna,Flavia Bazzoni,Marco A. Cassatella +8 more
TL;DR: In this study, intracellularly administered poly(I:C) stimulates human neutrophils to specifically express elevated mRNA levels encoding type I IFNs, immunoregulatory cytokines, and chemokines, so as to activate antiviral responses via helicase recognition, thus acting at the frontline of immunity against viruses.
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Viral sensors: diversity in pathogen recognition.
TL;DR: The current knowledge of viral sensors is reviewed, speculation on how they may function in vivo is speculated on, and the potential reasons for their diversity are explored.
RNA sensor–induced type I IFN prevents diabetes caused by a β cell–tropic virus in mice
Stephen A. McCartney,William Vermi,Silvia Lonardi,Cristina Rossini,Karel Otero,Boris Calderon,Susan Gilfillan,Michael S. Diamond,Emil R. Unanue,Marco Colonna +9 more
TL;DR: It is concluded that optimal functioning of viral sensors and prompt IFN-I responses are required to prevent diabetes when caused by a virus that infects and damages the β cells of the pancreas.
Melanoma differentiation-associated protein-5 (MDA-5) limits early viral replication but is not essential for the induction of type 1 interferons after Coxsackievirus infection
Michael Huhn,Stephen A. McCartney,Katharina Lind,Emma Svedin,Marco Colonna,Malin Flodström-Tullberg +5 more
TL;DR: It is indicated that MDA-5 plays an important role in the host immune response to CVB3 by preventing early virus replication and limiting tissue pathology.
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dsRNA sensors and plasmacytoid dendritic cells in host defense and autoimmunity
TL;DR: In this article, the authors summarize current knowledge of the diversity, specificity, and signaling pathways downstream of viral sensors and ask whether two distinct sensors that recognize the same viral component are complementary, compensatory, or simply redundant.
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