Stephanie Schubert
Hannover Medical School
21 Papers
142 Citations
Stephanie Schubert is an academic researcher from Hannover Medical School. The author has contributed to research in topics: Gene & Y chromosome. The author has an hindex of 9, co-authored 20 publications.
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Papers
Hspa4l-Deficient Mice Display Increased Incidence of Male Infertility and Hydronephrosis Development
Torsten Held,Ilona Paprotta,Janchiv Khulan,Bernhardt Hemmerlein,Lutz Binder,Stephan Wolf,Stephanie Schubert,Andreas Meinhardt,Wolfgang Engel,Ibrahim M. Adham +9 more
TL;DR: It is shown that Hspa4l is expressed ubiquitously and predominantly in the testis, and a role in osmotolerance is suggested.
Compartmentalization and regulation of iron metabolism proteins protect male germ cells from iron overload.
Yael Leichtmann-Bardoogo,Lyora A. Cohen,Avital Weiss,Britta Marohn,Stephanie Schubert,Andreas Meinhardt,Esther G. Meyron-Holtz +6 more
TL;DR: Examination of iron deposition and iron transport proteins in testes of mice with iron overload and with genetic ablation of the iron regulators Hfe and iron regulatory protein 2 shows evidence that ferritin secretion from Sertoli cells may play an important role in iron acquisition of primary spermatocytes.
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1,25-Dihydroxyvitamin D decreases HTRA1 promoter activity in the rhesus monkey--a plausible explanation for the influence of vitamin D on age-related macular degeneration?
Lisa Pahl,Stephanie Schubert,Britta Skawran,Maria Sandbothe,Jörg Schmidtke,Manfred Stuhrmann +5 more
TL;DR: The data point to a yet unexpected effect of decreased HTRA1 expression on drusen pathogenesis, which would impact current age-related macular degeneration research and treatment and require closer analysis.
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Generation and Characterization of a Transgenic Mouse with a Functional Human TSPY
Stephanie Schubert,Britta Skawran,F. Dechend,Karim Nayernia,Andreas Meinhardt,Indrajit Nanda,Michael Schmid,Wolfgang Engel,Jörg Schmidtke +8 more
TL;DR: The present study shows that a human TSPY gene integrated into the mouse genome follows the human expression pattern although murine tspy had lost its function in rodent evolution millions of years ago.
Characterization of the 10q26-orthologue in rhesus monkeys corroborates a functional connection between ARMS2 and HTRA1.
Lisa Pahl,Astrid Spangenberg,Stephanie Schubert,Uwe Schönmann,Jörg Schmidtke,Manfred Stuhrmann +5 more
TL;DR: The conserved linkage disequilibrium structure in humans and macaques goes in line with the recently emerged dual causality model proposing that ARMS2 and HTRA1 are functionally connected and that both genes contribute to the disease pathology.
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