Stéphanie Miard
Laval University
15 Papers
16 Citations
Stéphanie Miard is an academic researcher from Laval University. The author has contributed to research in topics: Biology & White adipose tissue. The author has an hindex of 7, co-authored 15 publications.
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Papers
Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation
Denis P. Blondin,Denis P. Blondin,Søren Nielsen,Eline N. Kuipers,Mai Charlotte Krogh Severinsen,V. Jensen,Stéphanie Miard,Naja Z. Jespersen,Sander Kooijman,Mariëtte R. Boon,Mélanie Fortin,Serge Phoenix,Serge Phoenix,Frédérique Frisch,Brigitte Guérin,Eric Turcotte,François Haman,Denis Richard,Frédéric Picard,Patrick C.N. Rensen,Camilla Scheele,André C. Carpentier,André C. Carpentier +22 more
TL;DR: It is reported that, in contrast to rodents, human BAT thermogenesis is not mediated by the stimulation of β3-AR, and pharmacological stimulation and inhibition of the β2-AR as well as knockdown of ADRB1, ADRB2, or ADRB3 in human brown adipocytes all confirmed that BAT lipolysis and thermogenesis occur through β2
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Hypoxia upregulates Malat1 expression through a CaMKK/AMPK/HIF-1α axis.
Sandrine Sallé-Lefort,Stéphanie Miard,Marc-André Nolin,Louise Boivin,Marie-Ève Paré,Richard Debigaré,Frédéric Picard +6 more
TL;DR: Findings strongly suggest that Malat1 expression is regulated in hypoxic conditions by a CaMKK/AMPK/HIF-1α axis and more research is needed in physiological settings to test the clinical relevance of this pathway.
Aging alters PPARγ in rodent and human adipose tissue by modulating the balance in steroid receptor coactivator‐1
TL;DR: It is shown that aging triggers changes in the transcriptional milieu of the nuclear receptor peroxisome proliferator‐activated receptor gamma (PPARγ) in vWAT, which leads to a modified potential for transactivation of target genes upon ligand treatment, which suggests that strategies aimed at increasing SRC‐1 expression and recruitment to PPARγ upon aging might help improve age‐associated metabolic disorders.
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Sirt1 Inhibits Resistin Expression in Aortic Stenosis
Sophie Carter,Stéphanie Miard,Catherine Roy-Bellavance,Louise Boivin,Zhuo Li,Philippe Pibarot,Patrick Mathieu,Frédéric Picard +7 more
TL;DR: It is demonstrated that, in calcified AS, levels of Sirt1 are reduced whereas those of resistin are increased within aortic valve leaflets, suggesting that modification of SIRT1 expression and/or activity could represent a novel approach against inflammation in AS.
IGFBP-2 partly mediates the early metabolic improvements caused by bariatric surgery
Justine Faramia,Zheng Hao,Michael B. Mumphrey,R. Leigh Townsend,Stéphanie Miard,Anne-Marie Carreau,Mélanie Nadeau,Frédérique Frisch,Elena-Dana Baraboi,Thomas Grenier-Larouche,Christophe Noll,Meng Li,Laurent Biertho,Simon Marceau,Frédéric-Simon Hould,Stéfane Lebel,Christopher D. Morrison,Heike Münzberg,Denis Richard,André C. Carpentier,André Tchernof,Hans-Rudolf Berthoud,Frédéric Picard +22 more
- 20 Apr 2021
TL;DR: In this paper, the authors showed that the modulation of circulating IGFBP-2 may play a role in the early improvement of insulin sensitivity and loss of adiposity brought about by bariatric surgery.
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