Stephanie L. Nott
University of Rochester
6 Papers
10 Citations
Stephanie L. Nott is an academic researcher from University of Rochester. The author has contributed to research in topics: Estrogen receptor & Estrogen. The author has an hindex of 4, co-authored 6 publications.
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Papers
Do Estrogen Receptor beta Polymorphisms Play A Role in the Pharmacogenetics of Estrogen Signaling
Stephanie L. Nott,Yanfang Huang,Brian R. Fluharty,Anna M Sokolov,Melinda Huang,Cathleen Cox,Mesut Muyan +6 more
TL;DR: This review aims to highlight the recent findings on polymorphisms of the lately identified ERbeta in order to provide a functional perspective with potential pharmacogenomic implications and an increasing body of evidence implicates ERalpha polymorphisms as one of the contributory factors for differential responses to estrogen competitors.
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What are comparative studies telling us about the mechanism of ERβ action in the ERE-dependent E2 signaling pathway? ☆
TL;DR: It appears that the lack of transactivation ability and of the capability of the amino-terminus of ERbeta, as opposed to that of ERalpha, to functionally interact with the carboxyl-terminal hormone-dependent activation domain is also critical for the receptor-specific activity.
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Designer monotransregulators provide a basis for a transcriptional therapy for de novo endocrine-resistant breast cancer.
Stephanie L. Nott,Yanfang Huang,Aja Kalkanoglu,Kathryn Harper,Ming Chen,Scott F. Paoni,Bruce M. Fenton,Mesut Muyan +7 more
TL;DR: Testing the prediction that specific regulation of ERE-driven genes by an engineered monomeric and constitutively active transcription factor, monotransregulator, provides a basis for the treatment of ER-negative breast cancer found that this approach could offer a therapeutic approach for de novo endocrine-resistant breast cancers.
3
Genomic Responses from the Estrogen-responsive Element-dependent Signaling Pathway Mediated by Estrogen Receptor α Are Required to Elicit Cellular Alterations
Stephanie L. Nott,Yanfang Huang,Xiaodong Li,Brian R. Fluharty,Xing Qiu,Wade V. Welshons,Shuyuan Yeh,Mesut Muyan +7 more
TL;DR: In this article, an ERE-binding defective ERα mutant (ERαEBD) was engineered by changing residues in an α-helix of the protein involved in DNA binding to render the receptor functional only through the EREindependent pathway.
Gene expression profiling reveals that the regulation of estrogen-responsive element-independent genes by 17 beta-estradiol-estrogen receptor beta is uncoupled from the induction of phenotypic changes in cell models.
Xiaodong Li,Stephanie L. Nott,Yanfang Huang,Russell Hilf,Robert A. Bambara,Xing Qiu,Andrei Yakovlev,Stephen Welle,Mesut Muyan +8 more
TL;DR: Although E(2)-ERbeta(EBD) regulated the expression of a number of genes identified by microarrays, it was ineffective in altering cellular proliferation, motility, and death in contrast to E( 2)-ER beta, suggesting that the ERE-dependent pathway is a required signaling route to induce cellular responses.