Stephanie Jung
German Cancer Research Center
5 Papers
Stephanie Jung is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 2, co-authored 2 publications. Previous affiliations of Stephanie Jung include Harvard University.
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Papers
Many roads to maturity: microRNA biogenesis pathways and their regulation
TL;DR: Recent advances in knowledge of the microRNA biosynthesis pathways are reviewed and their impact on post-transcriptional microRNA regulation during tumour development is discussed.
Coexpression of Argonaute-2 enhances RNA interference toward perfect match binding sites
Sven Diederichs,Stephanie Jung,S. Michael Rothenberg,Gromoslaw A. Smolen,Barbara G. Mlody,Daniel A. Haber +5 more
TL;DR: It is shown that ectopic expression of the RISC slicer Argonaute-2 (Ago2, eIF2C2) dramatically enhances RNAi specifically for mRNA targets with perfectly matched binding sites, which provides a strategy to enhance the efficacy and the specificity of RNAi in experimental and potentially therapeutic settings.
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Many Ways to Communicate—Crosstalk between the HBV-Infected Cell and Its Environment
TL;DR: In this paper , the authors discuss the impact of these interactions on viral persistence in chronic infection, as well as their relation to HBV infection-related pathology, and review how hepatitis B virus infection affects the communication between HBV-infected cells and cells in their environment.
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Identification of an Optimal TLR8 Ligand by Alternating the Position of 2′-O-Ribose Methylation
Marina Nicolai,Julia Steinberg,Hannah-Lena Obermann,Francisco Venegas Solis,Eva Bartok,Stefan Bauer,Stephanie Jung +6 more
TL;DR: This work designed different 2′-O-methylated RNA oligoribonucleotides (ORN), investigating their immune activity in various cell systems and analyzing degradation under RNase T2 treatment, and found that the 18S rRNA-derived TLR7/8 ligand, RNA63, was differentially digested as a result of2′- O-methylation, leading to variations in TLR8 and TLR 7 inhibition.
A fluorescent assay for cryptic transcription in Saccharomyces cerevisiae reveals novel insights into factors that stabilize chromatin structure on newly replicated chromatin
TL;DR: In this article , the authors show that DNA replication can promote cryptic transcription in S. cerevisiae, but only in G1-arrested cells, suggesting a requirement for DNA replication in chromatin disruption, and demonstrate modest cryptic transcription following the depletion of Rlf2/Cac1, a CAF-1 chromatin assembly complex component.