Stephania Guzman
Rutgers University
5 Papers
Stephania Guzman is an academic researcher from Rutgers University. The author has contributed to research in topics: Metastasis & Kisspeptins. The author has an hindex of 3, co-authored 4 publications. Previous affiliations of Stephania Guzman include City University of New York.
Chat about Author
Papers
A Machine Learning Approach for Using the Postmortem Skin Microbiome to Estimate the Postmortem Interval
Hunter Johnson,Donovan D Trinidad,Stephania Guzman,Zenab Khan,James V. Parziale,Jennifer M. DeBruyn,Nathan H. Lents +6 more
TL;DR: A machine learning approach for the use of necrobiome data in the prediction of the postmortem interval (PMI) of microbial samples is outlined, providing a successful proof-of- concept that skin microbiota is a promising tool in forensic death investigations.
KISS1/KISS1R in Cancer: Friend or Foe?
TL;DR: The purpose of this review is to highlight and discuss the clinical studies that have begun describing this relationship in varying cancer types including breast, liver, pancreatic, colorectal, bladder, and ovarian.
Targeting hepatic kisspeptin receptor ameliorates nonalcoholic fatty liver disease in a mouse model
Stephania Guzman,Magdalena Dragan,Hyokjoon Kwon,Vanessa de Oliveira,Shivani Rao,Vrushank Bhatt,Katarzyna Kalemba,Ankit Shah,Vinod K. Rustgi,Heng Wang,Paul Bech,Ali Abbara,Chioma Izzi-Engbeaya,Pinelopi Manousou,Jessie Yanxiang Guo,Grace L. Guo,Sally Radovick,Waljit S. Dhillo,Fredric E. Wondisford,Andy V. Babwah,Moshmi Bhattacharya +20 more
TL;DR: In patients with NAFLD and in high-fat diet–fed mice, hepatic KISS1/KISS1R expression and plasma kisspeptin levels were elevated, suggesting a compensatory mechanism to reduce triglyceride synthesis, and these findings establish KISS 1R as a therapeutic target to treat NASH.
19
KISS1/KISS1R and Breast Cancer: Metastasis Promoter.
Stephania Guzman,Muriel Brackstone,Frederic E. Wondisford,Andy V. Babwah,Moshmi Bhattacharya +4 more
TL;DR: This review summarizes recent developments in the understanding of the mechanisms by which KP/KISS1R signaling plays an adverse role in TNBC and focuses on how KISS1 R signaling regulates the cell cytoskeleton to induce tumor invadopodia formation.
15
G protein-coupled kisspeptin receptor induces metabolic reprograming and tumorigenesis in estrogen receptor-negative breast cancer
Magdalena Dragan,Mai Uyen Nguyen,Stephania Guzman,Cameron Goertzen,Muriel Brackstone,Waljit S. Dhillo,Paul Bech,Sophie A Clarke,Ali Abbara,Alan B. Tuck,David A. Hess,Sharon R. Pine,Wei-Xing Zong,Frederic E. Wondisford,Xiaoyang Su,Andy V. Babwah,Moshmi Bhattacharya +16 more
TL;DR: This study found that TNBC patients displayed elevated plasma kisspeptin levels compared with healthy subjects, and tracer-based metabolomics analyses revealed that KISS1R promoted glutaminolysis and nucleotide biosynthesis by increasing c-Myc and glutaminase levels, key regulators of glutamine metabolism.