Stephane Mouilleron
Francis Crick Institute
33 Papers
135 Citations
Stephane Mouilleron is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Biology & Glutaminase. The author has an hindex of 18, co-authored 31 publications. Previous affiliations of Stephane Mouilleron include Birkbeck, University of London & London Research Institute.
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Papers
Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins.
Martina Wirth,Wenxin Zhang,Minoo Razi,Lynet Nyoni,Dhira Joshi,Nicola O’Reilly,Terje Johansen,Sharon A. Tooze,Stephane Mouilleron +8 more
TL;DR: It is shown that in addition to the LIR motif also the region C-terminal of it is important for the binding specificity of both the centriolar satellite protein PCM1 and the ULK1 complex to GABARAP subfamily proteins.
Molecular basis for G‐actin binding to RPEL motifs from the serum response factor coactivator MAL
Stephane Mouilleron,Sebastian Guettler,Carola A. Langer,Richard Treisman,Neil Q. McDonald,Neil Q. McDonald +5 more
TL;DR: In this paper, the first molecular insights into RPEL function obtained from structures of two independent RPELMAL peptide:G-actin complexes were obtained from a cell reporter-based assays.
Structure of a pentavalent G-actin*MRTF-A complex reveals how G-actin controls nucleocytoplasmic shuttling of a transcriptional coactivator.
Stephane Mouilleron,Carola A. Langer,Sebastian Guettler,Neil Q. McDonald,Neil Q. McDonald,Richard Treisman +5 more
TL;DR: crystal structures of the actin-binding domain of MRTF-A reveal how increasing the concentration of monomeric actin—which leads to more molecules of actin binding to each molecule of MR TF-A—traps MRFT-A in the cytoplasm, preventing it from activating target genes, and signal-dependent changes in actin’s polymerization status can be directly coupled to changes in gene expression.
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ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8.
Mads Skytte Rasmussen,Stephane Mouilleron,Birendra Kumar Shrestha,Martina Wirth,Rebecca Lee,Kenneth Bowitz Larsen,Yakubu Abudu Princely,Nicola O’Reilly,Eva Sjøttem,Sharon A. Tooze,Trond Lamark,Terje Johansen +11 more
TL;DR: It is shown that ATG4B contains a C-terminal LC3-interacting region (LIR) motif important for efficient binding to and cleavage of LC3 and GABARAP proteins.
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Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs.
Åsa Birna Birgisdottir,Stephane Mouilleron,Zambarlal Bhujabal,Martina Wirth,Eva Sjøttem,Gry Evjen,Wenxin Zhang,Rebecca Lee,Nicola O’Reilly,Sharon A. Tooze,Trond Lamark,Terje Johansen +11 more
TL;DR: GABARAP-preferring LIR motifs in PIK3C3, BECN1 and ATG14 may, via coincidence detection, contribute to scaffolding of PtdIns3K-C1 on membranes for efficient autophagosome formation.
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