Stéphane Bernatchez
Health Canada
5 Papers
3 Citations
Stéphane Bernatchez is an academic researcher from Health Canada. The author has contributed to research in topics: Mesoporous silica & Dispersity. The author has an hindex of 4, co-authored 5 publications.
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Papers
Synthesis and physicochemical characterization of mesoporous SiO 2 nanoparticles
Dharani Das,Yong Yang,Julie S. O’Brien,Dalibor Breznan,Surendra Nimesh,Stéphane Bernatchez,Myriam Hill,Abdelhamid Sayari,Renaud Vincent,Prem Kumarathasan +9 more
TL;DR: In this paper, the authors synthesized a library of mesoporous silica nanoparticles with approximate particle sizes of 25, 70, 100, 170, and 600 nm and analyzed their morphology, surface functionality, surface area/pore volume, surface organic content, and dispersion characteristics in liquid media.
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Physicochemical Properties Can Be Key Determinants of Mesoporous Silica Nanoparticle Potency in Vitro
Dalibor Breznan,Dharani D. Das,Christine MacKinnon-Roy,Stéphane Bernatchez,Abdelhamid Sayari,Myriam Hill,Renaud Vincent,Prem Kumarathasan +7 more
TL;DR: It is indicated that newly synthesized mesoporous silica mSiNPs are less bioactive than the nonporous reference SiNP, and the integrated multilevel toxicity assessment approach can be valuable as a hazard screening tool for safety evaluations of emerging nanomaterials for regulatory purpose.
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A microbial identification framework for risk assessment.
TL;DR: A microbial identification framework for risk assessment (MIFRA) has been elaborated that serves to provide guidance on a polyphasic tiered approach, combining the data obtained from the use of various methods combined with the sequential selection of the methods to achieve a satisfactory identity of the micro-organism to an acceptable taxonomic level.
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Characterization of in vitro genotoxic, cytotoxic and transcriptomic responses following exposures to amorphous silica of different sizes.
Nathalie Decan,Dongmei Wu,Andrew Williams,Stéphane Bernatchez,Michael V. Johnston,Myriam Hill,Sabina Halappanavar +6 more
TL;DR: It is suggested that SiNPs induce cellular and genetic toxicity in a size-dependent manner and that the observed toxicity may be the results of higher particle internalization of smaller SiNP and subsequent lysosomal overload.
Differential cytotoxic and inflammatory potency of amorphous silicon dioxide nanoparticles of similar size in multiple cell lines.
Dalibor Breznan,Dharani Das,Julie S. O’Brien,Christine MacKinnon-Roy,Surendra Nimesh,Ngoc Q. Vuong,Stéphane Bernatchez,Nimal DeSilva,Myriam Hill,Prem Kumarathasan,Renaud Vincent +10 more
TL;DR: Particle surface acidity appeared to be the most significant determinant of the overall biological activity of this set of nanoparticles, and the approach shows promise as a useful tool for first-tier screening of SiNP toxicity.