Stephan Meller
University of Düsseldorf
69 Papers
347 Citations
Stephan Meller is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: Chemokine & Inflammation. The author has an hindex of 29, co-authored 69 publications. Previous affiliations of Stephan Meller include Ruhr University Bochum & University of Texas MD Anderson Cancer Center.
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Papers
Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA–Peptide Complexes in Systemic Lupus Erythematosus
Roberto Lande,Dipyaman Ganguly,Dipyaman Ganguly,Valeria Facchinetti,Loredana Frasca,Curdin Conrad,Josh Gregorio,Josh Gregorio,Stephan Meller,Georgios Chamilos,Rosalie Sebasigari,Valeria Riccieri,Roland L. Bassett,Hideki Amuro,Shirou Fukuhara,Tomoki Ito,Yong-Jun Liu,Michel Gilliet +17 more
TL;DR: An important role is shown for neutrophils in lupus pathogenesis, whereby neutrophil activated by anti-self antibodies release NETs, which contain antimicrobial peptides complexed with self-DNA and can entrap bacteria, enabling them to be killed.
IL-31: A new link between T cells and pruritus in atopic skin inflammation
Enikö Sonkoly,Anja Müller,Antti Lauerma,Andor Pivarcsi,Hortensia Soto,Lajos Kemény,Harri Alenius,Marie-Caroline Dieu-Nosjean,Stephan Meller,Juliane Rieker,Martin Steinhoff,Thomas K. Hoffmann,Thomas Ruzicka,Albert Zlotnik,Bernhard Homey +14 more
TL;DR: The findings provide a new link among staphylococcal colonization, subsequent T-cell recruitment/activation, and pruritus induction in patients with atopic dermatitis, and show that IL-31 may represent a novel target for antipruritic drug development.
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Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8
Dipyaman Ganguly,Georgios Chamilos,Roberto Lande,Josh Gregorio,Josh Gregorio,Stephan Meller,Valeria Facchinetti,Bernhard Homey,Franck J. Barrat,Tomasz Zal,Michel Gilliet,Michel Gilliet +11 more
TL;DR: It is demonstrated that the cationic antimicrobial peptide LL37 converts self-RNA into a trigger of TLR7 and TLR8 in human DCs, and provides new insights into the mechanism that drives the auto-inflammatory responses in psoriasis.
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Proteome-wide Analysis and CXCL4 as a Biomarker in Systemic Sclerosis
L. van Bon,L. van Bon,Alsya J. Affandi,Alsya J. Affandi,J. Broen,J. Broen,Romy B. Christmann,Renoud J. Marijnissen,Lukasz Stawski,Giuseppina Farina,Giuseppina Stifano,Allison L. Mathes,Marta Cossu,Michael York,Cindy Collins,Mark H. Wenink,R. Huijbens,Roger Hesselstrand,Tore Saxne,Michael DiMarzio,Dirk M. Wuttge,Sandeep K. Agarwal,John D. Reveille,Shervin Assassi,Maureen D. Mayes,Yanhui Deng,Joost P.H. Drenth,J. de Graaf,M. den Heijer,Cornelis Kallenberg,Marc Bijl,A. Loof,W.B. van den Berg,Leo A. B. Joosten,Vanessa Smith,F De Keyser,Raffaella Scorza,Claudio Lunardi,P.L.C.M. van Riel,Madelon C. Vonk,W.L. van Heerde,Stephan Meller,Bernhard Homey,Lorenzo Beretta,Mark Roest,Maria Trojanowska,Robert Lafyatis,Timothy R D J Radstake,Timothy R D J Radstake +48 more
TL;DR: Levels of CXCL4 were elevated in patients with systemic sclerosis and correlated with the presence and progression of complications, such as lung fibrosis and pulmonary arterial hypertension.
Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons.
Josh Gregorio,Josh Gregorio,Stephan Meller,Curdin Conrad,Anna Di Nardo,Bernhard Homey,Antti Lauerma,Naoko Arai,Richard L. Gallo,John DiGiovanni,Michel Gilliet,Michel Gilliet +11 more
TL;DR: Cutaneous injury in mice drives transient TLR7- and TLR9-mediated production of type I interferon by plasmacytoid dendritic cells, which is required for re-epithelialization of the skin.
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