N-Phenylpyrazole derivatives of the formula: ##STR1## wherein R 1 represents cyano, nitro, halogen, acetyl or formyl; R 2 represents R 5 SO 2 , R 5 SO or R 5 S in which R 5 is optionally halogen substituted alkyl, alkenyl or alkynyl; R 3 represents a hydrogen atom or a group NR 6 R 7 wherein R 6 and R 7 each represent hydrogen, alkyl, alkenylalkyl, alkynylalkyl, formyl, optionally halogen substituted alkanoyl, optionally halogen substituted alkoxycarbonyl, or alkoxymethyleneamino, halogen, or R 6 and R 7 together form a cyclic imide and R 4 represents a substituted phenyl group possess arthropodicidal, plant nematocidal, anthelmintic and anti-protozoal properties; their preparation, compositions containing them and their use are described.

Derivatives of N-phenylpyrazoles

The invention involves a method for making uniformly sized particles from water-insoluble drugs or other organic compounds. First, a suitable solid organic compound is dissolved in an organic solvent, and the solution can be diluted with a non-solvent. Then, an aqueous precipitating liquid is infused, precipitating non-aggregated particles with substantially uniform mean diameter. The particles are then separated from the organic solvent. Depending on the organic compound and the desired particle size, the parameters of temperature, ratio of non-solvent to organic solvent, infusion rate, stir rate, and volume can be varied according to the invention.

Method for making uniformly sized particles from water-insoluble organic compounds

The present invention provides microfluidic devices and methods for using the same. In particular, microfluidic devices of the present invention are useful in conducting a variety of assays and high throughput screening. Microfluidic devices of the present invention include elastomeric components and comprise a main flow channel; a plurality of branch flow channels; a plurality of control channels; and a plurality of valves. Preferably, each of the valves comprises one of the control channels and an elastomeric segment that is deflectable into or retractable from the main or branch flow channel upon which the valve operates in response to an actuation force applied to the control channel.

Apparatus and methods for conducting assays and high throughput screening

The present invention discloses methods for enhancing the wear-resistance of polymers, the resulting polymers, and in vivo implants made from such polymers. One aspect of this invention presents a method whereby a polymer is irradiated, preferably with gamma radiation, then thermally treated, such as by remelting of annealing. The resulting polymeric composition preferably has its most oxidized surface layer removed. Another aspect of the invention presents a general method for optimizing the wear resistance and desirable physical and/or chemical properties of a polymer by crosslinking and thermally treating it. The resulting polymeric compositions is wear-resistant and may be fabricated into an in vivo implant.

Crosslinking of polyethylene for low wear using radiation and thermal treatments

The isoxazolidine ring represents one of the privileged structures in medicinal chemistry, and there have been an increasing number of studies on isoxazolidine and isoxazolidine-containing compounds. Optimization of the 1,3-dipolar cycloaddition (1,3-DC), original methods including electrophilic or palladium-mediated cyclization of unsaturated hydroxylamine, has been developed to obtain isoxazolidines. Novel reactions involving the isoxazolidine ring have been highlighted to accomplish total synthesis or to obtain bioactive compounds, one of the most significant examples being probably the thermic ring contraction applied to the total synthesis of (±)-Gelsemoxonine. The unique isoxazolidine scaffold also exhibits an impressive potential as a mimic of nucleosides, carbohydrates, PNA, amino acids, and steroid analogs. This review aims to be a comprehensive and general summary of the different isoxazolidine syntheses, their use as starting building blocks for the preparation of natural compounds, and their m...

Isoxazolidine: A Privileged Scaffold for Organic and Medicinal Chemistry

3-Phenoxy-fluoro-benzyl carboxylic acid esters of the formula ##STR1## in which R2 is hydrogen, cyano or ethynyl, R3 is ##STR2## R4 and R5 represent chlorine, bromine or methyl, and R6 is phenyl or phenyl substituted with halogen, alkyl with 1 to 4 carbon atoms, alkoxy with 1 to 4 carbon atoms, nitro or methylenedioxy, which possess arthropodicidal properties. The alcohols are also new.

Combating arthropods with 3-phenoxy-fluoro-benzyl carboxylic acid esters

Benzoylureido-diphenyl ethers of the formula ##SPC1## In which One of R and R' is hydrogen and the other is chlorine, and R" is nitro or cyano, Which possess insecticidal properties.

Benzoylureido-diphenyl ether insecticides

These formulations consist of 0.1-20%, preferably 0.1-5%, of an insecticidal active substance; 1-40%, preferably 1-20%, of a gel-, coating- or film-forming polymer which is soluble or swellable both in water, in organic solvents or in mixtures of organic solvents and water; 40-98%, preferably 60-90% of water or an organic water/solvent mixture or an organic solvent; 0.1-10% of various additives such as spreading agents, antioxidants, dyes, plasticisers etc.

Formulations for fighting animal ectoparasites, in particular insects and acarides

2',4-Dichloro-4'-benzoylureido-diphenyl ethers of the formula ##STR1## in which R is chlorine, fluorine, bromine or methyl, and R' is hydrogen or chlorine, Which possess insecticidal properties.

2,4-Dichloro-4-benzoylureido-diphenyl ethers

The invention relates to ectoparasiticide-containing polyurethane collars for animals containing spreading agents and ectoparasiticides as well as methods for their manufacture.

Ectoparasiticide-containing collars for pets

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