Stéfany Chartier
Université de Montréal
6 Papers
1 Citations
Stéfany Chartier is an academic researcher from Université de Montréal. The author has contributed to research in topics: Kinase & Signal transduction. The author has an hindex of 3, co-authored 6 publications.
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Papers
IFNβ/TNFα synergism induces a non-canonical STAT2/IRF9-dependent pathway triggering a novel DUOX2 NADPH Oxidase-mediated airway antiviral response.
Karin Fink,Lydie Martin,Espérance Mukawera,Stéfany Chartier,Xavier De Deken,Emmanuelle Brochiero,Françoise Miot,Nathalie Grandvaux +7 more
TL;DR: A novel delayed antiviral response in the airways is unveiled, initiated by the synergistic autocrine/paracrine action of IFNβ and TNFα, and signals through a non-canonical STAT2- and IRF9-dependent, but STAT1-independent cascade, which ultimately leads to the late induction of the DUOX2 NADPH oxidase expression.
Pinpointing cysteine oxidation sites by high-resolution proteomics reveals a mechanism of redox-dependent inhibition of human STING.
TL;DR: In this article, a proteome-wide identification of reversibly oxidized cysteine sites in oxidant-treated cells using a maleimide-based bioswitch method coupled to mass spectrometry analysis is presented.
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Redox-modulating agents target NOX2-dependent IKKε oncogenic kinase expression and proliferation in human breast cancer cell lines
Espérance Mukawera,Stéfany Chartier,Virginie Williams,Patrick J. Pagano,Réjean Lapointe,Nathalie Grandvaux +5 more
TL;DR: It is shown that Gentian Violet, Brilliant Green and Tempol significantly decrease intracellular superoxide anion levels and inhibit IKKε expression and cell viability, suggesting that redox-modulating compounds targeting NOX2 could present a particular therapeutic interest in combination therapy against breast carcinomas exhibiting IKKα amplification.
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Sustained activation of interferon regulatory factor 3 during infection by paramyxoviruses requires MDA5.
Nathalie Grandvaux,Xiaochun Guan,Fabrice Yoboua,Nicolas Zucchini,Karin Fink,Priscilla Doyon,Lydie Martin,Marc J. Servant,Stéfany Chartier +8 more
TL;DR: A thorough analysis of the temporal involvement of RIG-I and MDA5 in the regulation of IRF-3 during respiratory syncytial virus (RSV) infection provides novel mechanistic insight into the innate antiviral response.