Stefano Cacchione
Sapienza University of Rome
49 Papers
198 Citations
Stefano Cacchione is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Nucleosome & Telomere. The author has an hindex of 18, co-authored 47 publications. Previous affiliations of Stefano Cacchione include Charles Darwin University & Laboratory of Molecular Biology.
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Papers
Chromatin Structure in Telomere Dynamics
TL;DR: Recent findings on chromatin modifications associated with the dynamic changes of telomeres from protected to deprotected state and their role in telomere functions are reviewed.
90
The main role of the sequence-dependent DNA elasticity in determining the free energy of nucleosome formation on telomeric DNAs
TL;DR: Both theoretical and experimental evaluations show that telomeres are characterized by the highest free energies of nucleosome formation among all the DNA sequences so far studied.
46
Emerging roles of telomeric chromatin alterations in cancer.
TL;DR: The current knowledge on the role of telomeric chromatin in neoplastic transformation, with a particular focus on H3.3 mutations in alternative lengthening of telomeres (ALT) cancers and sirtuin deacetylases dysfunctions is discussed.
AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance
Romina Burla,Mariateresa Carcuro,Grazia D. Raffa,Alessandra Galati,Domenico Raimondo,Angela Maria Rizzo,Mattia La Torre,Emanuela Micheli,Laura Ciapponi,Giovanni Cenci,Enrico Cundari,Antonio Musio,Annamaria Biroccio,Stefano Cacchione,Maurizio Gatti,Isabella Saggio +15 more
TL;DR: It is suggested that AKTIP/Ft1 works in concert with TRF1 to facilitate telomeric DNA replication, a novel mammalian shelterin-bound factor identified on the basis of its homology with the Drosophila telomere protein Pendolino.
TRF1 and TRF2 binding to telomeres is modulated by nucleosomal organization
Alessandra Galati,Emanuela Micheli,Claudia Alicata,Tiziano Ingegnere,Alessandro Cicconi,Miriam Caroline Pusch,Marie Josèphe Giraud-Panis,Eric Gilson,Stefano Cacchione +8 more
TL;DR: The results indicate that the different behavior of TRF proteins partly depends on the interaction with histone tails of their divergent N-terminal domains, and it is proposed that the interplay between the histone octamer and TRf proteins plays a role in the steps leading to telomere deprotection.