Stefanie Liening
University of Jena
10 Papers
12 Citations
Stefanie Liening is an academic researcher from University of Jena. The author has contributed to research in topics: Chemistry & Arachidonate 5-lipoxygenase. The author has an hindex of 7, co-authored 9 publications.
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Papers
Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo.
Thomas Hanke,Friederike Dehm,Stefanie Liening,Sven-Desiderius Popella,Jonas Maczewsky,Jonas Maczewsky,Max Pillong,Jens Kunze,Christina Weinigel,Dagmar Barz,Astrid Kaiser,Mario Wurglics,Michael Lämmerhofer,Gisbert Schneider,Lidia Sautebin,Manfred Schubert-Zsilavecz,Oliver Werz +16 more
TL;DR: Together, 2-aminothiazole-featured pirinixic acids represent potent dual 5-LO/mPGES-1 inhibitors with an attractive pharmacological profile as anti-inflammatory drugs.
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BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly
Ulrike Garscha,Susanna Voelker,Simona Pace,Jana Gerstmeier,Besa Emini,Stefanie Liening,Antonietta Rossi,Christina Weinigel,Silke Rummler,Ulrich S. Schubert,Gerhard K. E. Scriba,Erşan Çelikoğlu,Burcu Çalışkan,Erden Banoglu,Lidia Sautebin,Oliver Werz +15 more
TL;DR: Together, BRP-187 potently inhibits LT biosynthesis in vitro and in vivo, which seemingly is caused by preventing the 5-LO/FLAP complex assembly and warrants further preclinical evaluation.
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Melleolides from Honey Mushroom Inhibit 5-Lipoxygenase via Cys159.
Stefanie König,Erik Romp,Verena Krauth,Michael Rühl,Maximilian Dörfer,Stefanie Liening,Bettina Hofmann,Ann-Kathrin Häfner,Dieter Steinhilber,Michael Karas,Ulrike Garscha,Dirk Hoffmeister,Oliver Werz +12 more
TL;DR: Melleolides inhibit 5-LO via an α,β-unsaturated aldehyde serving as Michael acceptor for surface cysteines at the substrate entrance that are revealed as molecular determinants for 5- LO activity.
15
Development of smart cell-free and cell-based assay systems for investigation of leukotriene C4 synthase activity and evaluation of inhibitors
Stefanie Liening,Gerhard K. E. Scriba,Silke Rummler,Christina Weinigel,Thea Kleinschmidt,Jesper Z. Haeggström,Oliver Werz,Ulrike Garscha +7 more
TL;DR: Smart cell-free and cell-based assay systems based on in situ-generated LTA4 are presented, suitable for studying enzymatic functionality of LTC4S including site-directed mutations and evaluation of L TC4S inhibitors.
12
Liquid chromatography-coupled mass spectrometry analysis of glutathione conjugates of oxygenated polyunsaturated fatty acids
TL;DR: The method was employed to detect GSH conjugates in human platelets and macrophages and gives an analytical basis for the detection and structural elucidation of cysteinyl-containing lipid mediators.
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