Stefan E. Spycher
University of Bern
17 Papers
631 Citations
Stefan E. Spycher is an academic researcher from University of Bern. The author has contributed to research in topics: Signal transduction & Protein kinase C. The author has an hindex of 12, co-authored 16 publications.
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Papers
A novel human tocopherol-associated protein: cloning, in vitro expression, and characterization.
Sabine Zimmer,Achim Stocker,Mohammad N. Sarbolouki,Stefan E. Spycher,Judyth Sassoon,Angelo Azzi +5 more
TL;DR: HTAP binds to α-tocopherol and biotinylated tocopherol, suggesting the existence of a hydrophobic pocket, possibly analogous to that of SEC14.
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Involvement of oxidants and oxidant-generating enzyme(s) in tumour-necrosis-factor-alpha-mediated apoptosis: role for lipoxygenase pathway but not mitochondrial respiratory chain.
TL;DR: It is suggested that neither H2O2 nor O2-.
167
Specific Cellular Responses to α-Tocopherol
Angelo Azzi,Isabel Breyer,Maria Feher,Mariella Pastori,Roberta Ricciarelli,Stefan E. Spycher,Mariagrazia Staffieri,Achim Stocker,Sabine Zimmer,Jean-Marc Zingg +9 more
TL;DR: In the last 10 years precise cellular functions of alpha-tocopherol have been revealed as discussed by the authors, some of which are independent of its antioxidant/radical-scavenging ability.
Aldose reductase induction: a novel response to oxidative stress of smooth muscle cells.
TL;DR: Data indicate that the induction of aldose reductase during oxidative stress might represent an important cellular antioxidant defense mecha‐nism and inclusion of Sorbinil in toxicity assays resulted in a significant (twofold) enhancement of HNE‐mediated killing of A7r5 cells, suggesting a protective role of a Aldose reduCTase against H NE‐induced cell death.
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Molecular basis of α‐tocopherol control of smooth muscle cell proliferation
Angelo Azzi,Elisabetta Aratri,D. Boscoboinik,Sophie Clément,Nesrin Kartal Ozer,Roberta Ricciarelli,Stefan E. Spycher +6 more
TL;DR: It is proposed that, by inhibiting protein kinase C activity via an activation of a phosphatase PP2A, α‐tocopherol controls smooth muscle cell proliferation through changes in gene expression.
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