Stanley Ng
ImClone Systems
8 Papers
50 Citations
Stanley Ng is an academic researcher from ImClone Systems. The author has contributed to research in topics: Antibody & Cetuximab. The author has an hindex of 7, co-authored 8 publications. Previous affiliations of Stanley Ng include Eli Lilly and Company.
Chat about Author
Papers
Anti-transforming growth factor beta receptor II antibody has therapeutic efficacy against primary tumor growth and metastasis through multieffects on cancer, stroma, and immune cells
Zhaojing Zhong,Kyla Carroll,Desiree Policarpio,Carla Osborn,Michael Gregory,Rajiv Bassi,Xenia Jimenez,Marie Prewett,Gregory W. Liebisch,Kris Persaud,Douglas Burtrum,Su Wang,David Surguladze,Stanley Ng,Heather Griffith,Paul Balderes,Jacqueline Doody,Jonathan D. Schwartz,Hagop Youssoufian,Eric K. Rowinsky,Dale L. Ludwig,Larry Witte,Zhenping Zhu,Yan Wu +23 more
TL;DR: These preclinical data provide a foundation to support using anti–TGFβ RII antibody as a therapeutic agent for TGF β RII–dependent cancer with metastatic capacity.
122
IgG isotype, glycosylation, and EGFR expression determine the induction of antibody-dependent cellular cytotoxicity in vitro by cetuximab
Dipa Patel,Xuemei Guo,Stanley Ng,Maxine Melchior,Paul Balderes,Douglas Burtrum,Kris Persaud,Xenia Luna,Dale L. Ludwig,Xiaoqiang Kang +9 more
TL;DR: Findings suggest that ADCC may contribute to the antitumor activity of cetuximab, an anti-epidermal growth factor receptor (EGFR) IgG1 antibody, in vitro.
76
Development of a novel and efficient cell culture flocculation process using a stimulus responsive polymer to streamline antibody purification processes
Yun Kenneth Kang,James Hamzik,Michael Felo,Bo Qi,Julia Lee,Stanley Ng,Gregory W. Liebisch,Behnam Shanehsaz,Nripen Singh,Kris Persaud,Dale L. Ludwig,Paul Balderes +11 more
TL;DR: An alternative antibody harvest process that incorporates flocculation using a novel stimulus responsive polymer, benzylated poly(allylamine), followed by depth filtration, which demonstrates high process yield, improved clearance of cells and cell debris, and efficient reduction of aggregates, host cell proteins (HCP) and DNA.
69
High affinity Fc receptor binding and potent induction of antibody-dependent cellular cytotoxicity (ADCC) in vitro by anti-epidermal growth factor receptor antibody cetuximab
TL;DR: This study tested whether cetuximab can elicit antibody-dependent cellular cytotoxicity (ADCC) in vitro using tumor cell lines expressing various levels of EGFR and found that cetUXimab-induced ADCC to these tumor cells was found to be successful.
24
Removal of a C-terminal serine residue proximal to the inter-chain disulfide bond of a human IgG1 lambda light chain mediates enhanced antibody stability and antibody dependent cell-mediated cytotoxicity.
Yang Shen,Lin Zeng,Aiping Zhu,Tim Blanc,Dipa Patel,Anthony Pennello,Amtul Bari,Stanley Ng,Kris Persaud,Yun Kenneth Kang,Paul Balderes,David Surguladze,Sagit Hindi,Qinwei Zhou,Dale L. Ludwig,Marshall Snavely +15 more
TL;DR: Observations support the conclusion that the presence of the terminal serine of the λ Lc creates a weaker inter-chain disulfide bond between the Lc and Hc, leading to slightly reduced stability and a potential compromise in IgG1λ function.
21