Stanley H. Appel
Houston Methodist Hospital
452 Papers
6.3K Citations
Stanley H. Appel is an academic researcher from Houston Methodist Hospital. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Medicine. The author has an hindex of 97, co-authored 443 publications. Previous affiliations of Stanley H. Appel include University of Pennsylvania & Baylor University.
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Papers
Prognosis of amyotrophic lateral sclerosis and the effect of referral selection
TL;DR: In both cohorts, older age at diagnosis, bulbar onset, and positive family history of ALS were unfavorable prognostic factors while blacks had better survival than whites or hispanics, and longer duration from onset to diagnosis was a favorable prognostic factor but the effect was more pronounced in the referral series.
Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis
Stanley H. Appel,József I. Engelhardt,Jenny S. Henkel,László Siklós,David R. Beers,Albert A. Yen,Ericka Simpson,Y. Luo,George Carrum,Helen E. Heslop,Malcolm K. Brenner,Uday Popat +11 more
TL;DR: This study demonstrates that peripheral cells derived from donor hematopoietic stem cells can enter the human CNS primarily at sites of motoneuron pathology and engraft as immunomodulatory cells.
Is there acetylcholine receptor in human thymus
TL;DR: Neither normal nor myasthenic thymus tissue were found to possess the [125I] alpha-bungarotoxin binding or the antigenic properties of the acetylcholine receptor.
Nigral damage and dopaminergic hypofunction in mesencephalon-immunized guinea pigs
Stanley H. Appel,Wei‐Dong ‐D Le,János Tajti,Lanny J. Haverkamp,József I. Engelhardt,József I. Engelhardt +5 more
TL;DR: The antigenicity of SN is documented and the possibility that immune mechanisms can contribute to basal ganglia pathology is suggested, to support a potential role for immune mechanisms in the destruction of substantia nigra neurons.
Decremental motor responses to repetitive nerve stimulation in ALS
TL;DR: The finding that at least 50% of ALS patients show some degree of decrement on RNS of the trapezius muscle suggests that functional alterations of the neuromuscular junction accompany this disease.