Staffan Normark
Karolinska Institutet
292 Papers
6K Citations
Staffan Normark is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Pilus & Bacterial adhesin. The author has an hindex of 96, co-authored 289 publications. Previous affiliations of Staffan Normark include Swedish Institute & Royal Swedish Academy of Sciences.
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Papers
Nucleotide sequence of the papA gene encoding the Pap pilus subunit of human uropathogenic Escherichia coli.
M Båga,Staffan Normark,Jonathan Hardy,P O'Hanley,D Lark,Olof Olsson,Gary K. Schoolnik,Stanley Falkow +7 more
TL;DR: The papA gene of the uropathogenic strain Escherichia coli J96, coding for the Pap pili subunit, was subjected to DNA sequencing, and found to code for an 185-amino acid-long polypeptide with a 22-amINO acid- long signal peptide.
157
Inactivation of the ampD gene causes semiconstitutive overproduction of the inducible Citrobacter freundii beta-lactamase.
TL;DR: It is hypothesized that induction of beta-lactamase synthesis is caused by blocking of the AmpD function by the beta- lactam inducer and that this leads directly or indirectly to an AmpR-mediated stimulation of ampC expression.
156
The Crl protein activates cryptic genes for curli formation and fibronectin binding in Escherichia coli HB101.
TL;DR: The subunit protein of curli was highly homologous at its amino terminus to SEF‐17, the subunitprotein of thin, aggregative fimbriae of Salmonella enteritidis 27655 strain 3b, suggesting that these fibres form a novel class of surface organelles on enterobacteria.
156
Availability of the fibre subunit CsgA and the nucleator protein CsgB during assembly of fibronectin-binding curli is limited by the intracellular concentration of the novel lipoprotein CsgG
TL;DR: It is demonstrated that curli production and steady‐state levels of CsgA and CsgB can be increased above wild‐type levels by overexpressing CsgG, meaning that the quantity of assembled curli fibres can be controlled by this lipoprotein.
154
Gastric Mucosal Recognition of Helicobacter pylori Is Independent of Toll-Like Receptor 4
Fredrik Bäckhed,Bachra Rokbi,Elisabeth Torstensson,Ying Zhao,Christina Nilsson,Delphine Seguin,Staffan Normark,Alison M.J. Buchan,Agneta Richter-Dahlfors +8 more
TL;DR: Findings indicate that, although the epithelium is important in directing the immune response against H. pylori infections, the response is independent of TLR4.
152