Staffan Normark
Karolinska Institutet
292 Papers
6K Citations
Staffan Normark is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Pilus & Bacterial adhesin. The author has an hindex of 96, co-authored 289 publications. Previous affiliations of Staffan Normark include Swedish Institute & Royal Swedish Academy of Sciences.
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Papers
Uropathogenic, Escherichia coli can express serologically identical pili of different receptor binding specificities
Björn Lund,Britt-Inger Marklund,Nicklas Strömberg,Frederik Lindberg,K.-A. Karlsson,Staffan Normark +5 more
TL;DR: A novel gene cluster from J96, prs, is described, which is responsible for the agglutination of sheep erythrocytes and is the first direct evidence that serologically identical pili may present antigenically distinct adhesins, each capable of binding to a specific receptor.
170
Biogenesis of E. coli Pap pili: PapH, a minor pilin subunit involved in cell anchoring and length modulation
TL;DR: The data show that PapH has roles in anchoring the pilus to the cell and in modulating pilus length, and coregulation of papH and the adjacent gene, papA, which encodes the major pilin subunit is presented.
167
Transcriptional activation of a pap pilus virulence operon from uropathogenic Escherichia coli.
TL;DR: A gene cluster mediating production of pili in uropathogenic Escherichia coli was analysed and full expression of papA was cis dependent upon the papI‐papB region, and transcription of the papB gene was shown to be dependent upon cAMP and its receptor protein.
166
Binding of the Citrobacter freundii AmpR regulator to a single DNA site provides both autoregulation and activation of the inducible ampC beta-lactamase gene.
TL;DR: It is shown that the AmpR protein acts as a transcriptional activator by binding to a DNA region immediately upstream of the ampC promoter, which suggests that ampR is autogenously controlled.
161
Initiation of assembly and association of the structural elements of a bacterial pilus depend on two specialized tip proteins.
TL;DR: It is suggested that in addition to the adaptor functions of PapF and PapK, they are also required to initiate the formation of tip fibrillae and pilus rods.