Staffan Normark
Karolinska Institutet
292 Papers
6K Citations
Staffan Normark is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Pilus & Bacterial adhesin. The author has an hindex of 96, co-authored 289 publications. Previous affiliations of Staffan Normark include Swedish Institute & Royal Swedish Academy of Sciences.
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Papers
Role of Escherichia coli Curli Operons in Directing Amyloid Fiber Formation
Matthew George Chapman,Lloyd S. Robinson,Jerome S. Pinkner,Robyn Roth,John E. Heuser,Mårten Hammar,Staffan Normark,Scott J. Hultgren +7 more
TL;DR: Biochemical, biophysical, and imaging analyses revealed that fibers produced by Escherichia coli called curli were amyloid, and curli biogenesis was dependent on the nucleation-precipitation machinery requiring the CsgE and CsgF chaperone-like and nucleator proteins, respectively.
Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens
TL;DR: Bacteria did not bind to Leb antigen substituted with a terminal GalNAc alpha 1-3 residue (blood group A determinant), suggesting that the availability of H. pylori receptors might be reduced in individuals of blood group A and B phenotypes, as compared with blood group O individuals.
1.2K
Fibronectin binding mediated by a novel class of surface organelles on Escherichia coli.
TL;DR: The ability of curli to mediate binding to fibronectin may be a virulence-associated property for wound colonization and for the colonization of fibronECTin-coated surfaces.
628
Bacterial adhesins in host-microbe interactions.
Kimberly A. Kline,Kimberly A. Kline,Stefan Fälker,Sofia Dahlberg,Staffan Normark,Birgitta Henriques-Normark +5 more
TL;DR: This review will focus on the interaction between bacterial adhesins and the host, with an emphasis on pilus-like structures.
619
An Endonuclease Allows Streptococcus pneumoniae to Escape from Neutrophil Extracellular Traps
Katharina Beiter,Florian Wartha,Barbara Albiger,Staffan Normark,Arturo Zychlinsky,Birgitta Henriques-Normark +5 more
TL;DR: Pneumococci are trapped but, unlike many other pathogens, not killed by NETs, and it is demonstrated that escaping NETs promotes spreading of pneumococci from the upper airways to the lungs and from the lungs into the bloodstream during pneumonia.
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