Staci E. Engle
Indiana University – Purdue University Indianapolis
28 Papers
112 Citations
Staci E. Engle is an academic researcher from Indiana University – Purdue University Indianapolis. The author has contributed to research in topics: Cilium & Nicotinic agonist. The author has an hindex of 12, co-authored 24 publications. Previous affiliations of Staci E. Engle include Purdue University & Case Western Reserve University.
Chat about Author
Papers
Differential expression and function of nicotinic acetylcholine receptors in subdivisions of medial habenula
Pei Yu Shih,Staci E. Engle,GYeon Oh,Purnima Deshpande,Nyssa L. Puskar,Henry A. Lester,Ryan M. Drenan +6 more
TL;DR: It is found that α3 and β4 nAChR subunit levels are strong throughout the ventral MHb (MHbV) and α6, β2, β3, and α4 subunits are selectively found in some, but not all, areas of MHbV.
122
α4α6β2* nicotinic acetylcholine receptor activation on ventral tegmental area dopamine neurons is sufficient to stimulate a depolarizing conductance and enhance surface AMPA receptor function.
TL;DR: It is suggested that activation of α4α6β2* nAChRs in VTA DA neurons is sufficient to support the initiation of cellular changes that play a role in addiction to nicotine.
48
Nicotine and ethanol cooperate to enhance ventral tegmental area AMPA receptor function via α6-containing nicotinic receptors
TL;DR: Low concentrations of nicotine and ethanol that were capable of strongly enhancing VTA AMPAR function when co-applied to slices were identified, but that did not enhance AM PAR function when applied alone.
32
α6-Containing nicotinic acetylcholine receptors in midbrain dopamine neurons are poised to govern dopamine-mediated behaviors and synaptic plasticity.
TL;DR: It is shown that activating α6(∗) nAChRs in midbrain DA areas is sufficient to enhance glutamatergic transmission in ventral tegmental area (VTA) DA neurons and to support plasticity changes in mid brain DA neurons that are relevant to behavioral sensitization and addiction.
26
Local application of drugs to study nicotinic acetylcholine receptor function in mouse brain slices.
TL;DR: A method for rapidly applying nAChR-activating drugs to neurons recorded in adult mouse brain slices is described and should be useful for studying many types of ligand-gated ion channels or receptors in neurons from brain slices.