Sridhar Nimmagadda
Johns Hopkins University
117 Papers
506 Citations
Sridhar Nimmagadda is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Medicine & Biodistribution. The author has an hindex of 34, co-authored 95 publications. Previous affiliations of Sridhar Nimmagadda include University of Freiburg & Johns Hopkins University School of Medicine.
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Papers
CXCR4-Based Imaging Agents
TL;DR: Because CXCR4 is constitutively expressed in a wide variety of normal tissues, patient stratification and noninvasive monitoring would improve therapeutic outcome and reduce unnecessary toxicities.
Structural characterization and in vivo evaluation of β-Hairpin peptidomimetics as specific CXCR4 imaging agents.
Wojciech G. Lesniak,Emilia Sikorska,Hassan M. Shallal,Babak Behnam Azad,Ala Lisok,Mrudula Pullambhatla,Martin G. Pomper,Sridhar Nimmagadda +7 more
TL;DR: In silico and in vitro studies show that POL3026 and its conjugates demonstrate similar interactions with different micelles that mimic cellular membrane and that the ε-NH2 of lysine(7) is critical to maintain high affinity to CXCR4.
Low-Level Endogenous PSMA Expression in Nonprostatic Tumor Xenografts Is Sufficient for In Vivo Tumor Targeting and Imaging.
Sridhar Nimmagadda,Mrudula Pullambhatla,Ying Chen,Princy Parsana,Ala Lisok,Samit Chatterjee,Ronnie C. Mease,Steven P. Rowe,Shawn E. Lupold,Kenneth J. Pienta,Martin G. Pomper +10 more
TL;DR: The results indicate that PSMA expression in nonprostatic tumors may not be limited to the endothelium but may also include solid tumor tissue of non Prostate-specific membrane antigen cancers including melanoma and SCLC.
Comparison of skeletal and soft tissue pericytes identifies CXCR4 + bone forming mural cells in human tissues
Jiajia Xu,Dongqing Li,Dongqing Li,Ching Yun Hsu,Ye Tian,Leititia Zhang,Leititia Zhang,Yiyun Wang,Robert J. Tower,Leslie Chang,Carolyn A. Meyers,Yongxing Gao,Kristen P. Broderick,Carol D. Morris,Jody E. Hooper,Sridhar Nimmagadda,Bruno Péault,Bruno Péault,Aaron W. James,Aaron W. James +19 more
TL;DR: Diversity exists in soft tissue pericytes, however, and CXCR4+ pericyte represents an osteoblastogenic, non-adipocytic cell precursor, and enrichment for CX CR4-expressing stromal cells is a potential new tactic for skeletal tissue engineering.
64Cu-labeled inhibitors of prostate-specific membrane antigen for PET imaging of prostate cancer
Sangeeta Ray Banerjee,Mrudula Pullambhatla,Catherine A. Foss,Sridhar Nimmagadda,Riccardo Ferdani,Carolyn J. Anderson,Ronnie C. Mease,Martin G. Pomper +7 more
TL;DR: Five 64Cu-labeled inhibitors of PSMA, [64Cu]3–7, which are based on the lysine–glutamate urea scaffold and utilize a variety of macrocyclic chelators, are reported, to determine which provides the most suitable pharmacokinetics for in vivo PET imaging.