The clinical and histologic findings in eighty-five cases of tumors metastatic to the umbilicus were studied. Clinically, the lesions were seen as firm, indurated nodules, sometimes with fissuring or ulceration. In twelve cases, the initial presentation of the internal primary malignancy was an umbilical nodule. Histologic material from the metastatic umbilical tumor was studied in all cases but was diagnostic of the primary carcinoma in only twenty-one. In seventeen cases, the primary site was never reliably determined, while stomach, large bowel, ovary, and pancreas were the most frequent primary sites in the other cases. Most patients died within months after the appearance of the umbilical tumors, thus emphasizing the ominous significance of this sign of metastatic, usually intra-abdominal, malignant disease. (J AM ACRD DERMATOL 10:610-615, 1984.)

https://www.jaad.org/article/S0190-9622(84)80265-0/pdf

Sister Mary Joseph's nodule: A clinical and histologic study

Despite awareness of the wide variety of clinical and laboratory abnormalities associated with alcohol abuse, drinking problems often remain undetected in hospital and in general medical practice. The diagnosis of alcohol abuse has been emphasized repeatedly in the literature but far less attention has been paid to indicators that would permit detection of excessive drinking at a stage when intervention might be more effective and less costly. The search for indicators of early alcohol abuse is complicated since many of the medical sequelae of alcoholism are nonspecific and may only be manifested after a number of years of excessive drinking. Part 2 of this two-part series considers various clinical and laboratory features related to alcohol abuse and highlights items that are potentially more sensitive for detecting early stages of problem drinking. Use by physicians of a composite profile of both biomedical and psychosocial indicators of excessive alcohol consumption is recommended for early identification of this problem.

Early identification of alcohol abuse: 2: Clinical and laboratory indicators

This letter relates to the increased number of multiple fibroadenomas seen in women receiving hormonal contraceptives. 12 patients aged 17-30 years were found to have 2-4 nodules which increased rapidly in size while on oral contraceptives and prompted surgical intervention.

Multiple breast fibroadenomas in women on hormonal contraceptives.

Pearl, Raymond (1879-1940)

Introduction
Umbilical metastasis (Sister Mary Joseph’s nodule) is rare. It is encountered in 1–3% of patients with intra-abdominal and/or pelvic malignancy, with gastric carcinoma being the commonest origin in men and ovarian carcinoma—in women. Only 27 cases of Sister Mary Joseph’s nodule originating from endometrial carcinoma have previously been documented in the literature.

Sister Mary Joseph’s nodule originating from endometrial carcinoma incidentally detected during surgery for an umbilical hernia: a case report

STRlIlIft"BN, D. H. P., DOISY, R. J., GBRSTIDIN, M. M., and MARINOR, B. M. (1965>, "Reduced Glucose Tolerance In Elderly Human Subjects", Diabetes, 14: 579. TsUSKETT, I. D., and CONSTABLE, W. C. (1968), "Management of Carcinoma of the Corpus Uteri", Amer. J. Obstet. Gvnee., 101: 689. VANDBR, J. B. (1959), "The Association of Diabetes Mellltus and Carcinoma of the Endometrium", Amer. J. Obstet. Gvnee., 77: 243. WAY, S. (1954), "The lEtiology of Carcinoma of the Body of the Uterus", J. Obstet. Gvnme. Brit. Emp., 61: 46.

Sister joseph's nodule

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Sister joseph's nodule