31 Papers
396 Citations
SP Hunt is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Substance P & Hyperalgesia. The author has an hindex of 19, co-authored 31 publications.
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Papers
Altered nociception, analgesia and aggression in mice lacking the receptor for substance P.
Carmen De Felipe,Juan Herrero,John A. O'Brien,JA Palmer,Christopher A. Doyle,Andrew J.H. Smith,Jennifer M.A. Laird,Carlos Belmonte,Fernando Cervero,SP Hunt +9 more
TL;DR: Although substance P did not mediate the signalling of acute pain or hyperalgesia, it was essential for the full development of stress-induced analgesia and for an aggressive response to territorial challenge, demonstrating that the peptide plays an unexpected role in the adaptive response to stress.
797
Netrin and netrin receptor expression in the embryonic mammalian nervous system suggests roles in retinal, striatal, nigral, and cerebellar development.
Frederick J. Livesey,SP Hunt +1 more
TL;DR: The localization of cells expressing netrin or dcc suggests that these genes, in addition to their actions in defining the ventral midline, may act in controlling retinal ganglion cell axon guidance in the optic nerve, cell migration in the developing cerebellum and olfactory epithelium, and development and maintenance of connections to the substantia nigra and corpus striatum.
195
A Schwann cell mitogen accompanying regeneration of motor neurons.
Frederick J. Livesey,Frederick J. Livesey,John A. O'Brien,Meng Li,Austin Smith,Liam J. Murphy,SP Hunt +6 more
TL;DR: The identification, using a technique known as messenger RNA differential display, of an extracellular signalling molecule, previously described as the pancreatic secreted protein Reg-2, that is expressed solely in regenerating and developing rat motor and sensory neurons is reported here.
191
Comparison of the phenotype of NK1R-/- mice with pharmacological blockade of the substance P (NK1) receptor in assays for antidepressant and anxiolytic drugs
Nadia M.J. Rupniak,Emma J. Carlson,J.K. Webb,T. Harrison,R.D. Porsolt,S. Roux,C. de Felipe,SP Hunt,B. Oates,Alan Wheeldon +9 more
TL;DR: Previous observations on the phenotype of the NK1R−/− mouse are extended and a broadly similar profile following acute pharmacological blockade of the receptor is established, to underscore the limitations of currently available antagonists that are suitable for use in rat and mouse behavioural assays.
151
The differential control of c-jun expression in regenerating sensory neurons and their associated glial cells
C De Felipe,SP Hunt +1 more
TL;DR: It is suggested that c-jun levels are differentially regulated in neurons and glial cells but that NGF or BDNF do not regulate c-Jun expression in damaged neurons.
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