Sourav Roy Choudhury
University of Massachusetts Medical School
6 Papers
Sourav Roy Choudhury is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Transduction (genetics) & Gene delivery. The author has an hindex of 4, co-authored 6 publications.
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Papers
Viral vectors for therapy of neurologic diseases.
Sourav Roy Choudhury,Eloise Hudry,Casey A. Maguire,Miguel Sena-Esteves,Xandra O. Breakefield,Paola Grandi +5 more
TL;DR: An overview of the current state and advances in the field of viral vector-mediated gene therapy for neurological disorders is provided, as well as preclinical and clinical progress made thus far for brain cancer and various neurodegenerative and neurometabolic disorders.
182
In Vivo Selection Yields AAV-B1 Capsid for Central Nervous System and Muscle Gene Therapy
Sourav Roy Choudhury,Zachary Fitzpatrick,Anne F Harris,Stacy Maitland,Jennifer S Ferreira,Yuanfan Zhang,Shan Ma,Rohit Sharma,Heather L. Gray-Edwards,Jacob A. Johnson,Aime K. Johnson,Laura C. Alonso,Claudio Punzo,Kathryn R. Wagner,Casey A. Maguire,Robert M. Kotin,Douglas R. Martin,Miguel Sena-Esteves +17 more
TL;DR: The isolation of a novel CNS tropic AAV capsid, AAV-B1, after a single round of in vivo selection from an AAV Capsid library is reported, which represents an important improvement over AAV9 for CNS gene therapy.
120
Widespread Central Nervous System Gene Transfer and Silencing After Systemic Delivery of Novel AAV-AS Vector
Sourav Roy Choudhury,Anne F Harris,Damien J. Cabral,Allison M. Keeler,Ellen Sapp,Jennifer S Ferreira,Heather L. Gray-Edwards,Jacob A. Johnson,Aime K. Johnson,Qin Su,Lorelei Stoica,Marian DiFiglia,Neil Aronin,Douglas R. Martin,Guangping Gao,Miguel Sena-Esteves +15 more
TL;DR: This work investigated the possibility of improving CNS transduction of existing AAV capsids by genetically fusing peptides to the N-terminus of VP2 capsid protein, and found a novel vector AAV-AS, generated by the insertion of a poly-alanine peptide, is capable of extensive gene transfer throughout the CNS after systemic administration in adult mice.
107
Systemic Delivery of AAVB1-GAA Clears Glycogen and Prolongs Survival in a Mouse Model of Pompe Disease.
Allison M. Keeler,Marina Zieger,Sophia H. Todeasa,Angela L McCall,Jennifer C. Gifford,Samantha Birsak,Sourav Roy Choudhury,Barry J. Byrne,Miguel Sena-Esteves,Mai K. ElMallah,Mai K. ElMallah +10 more
TL;DR: AAVB1-GAA offers a promising therapeutic option for the treatment of muscle and CNS in Pompe disease and shows improved respiratory function comparable to wild-type animals.
38
Patent
Nouveaux vecteurs aav identifiés au moyen de banques à efficacité élevée
Miguel Sena Esteves,Sourav Roy Choudhury +1 more
- 02 Oct 2015
TL;DR: In this article, the authors describe aspects de la presente invention concernent des banques de capsides AAV chimeres a code barres, des capsides chimesres and des rAAV associes.