Souji Eda
12 Papers
174 Citations
Souji Eda is an academic researcher. The author has contributed to research in topics: Collectin & Conglutinin. The author has an hindex of 12, co-authored 12 publications.
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Papers
The membrane-type collectin CL-P1 is a scavenger receptor on vascular endothelial cells.
Katsuki Ohtani,Yasuhiko Suzuki,Souji Eda,Takao Kawai,Tetsuo Kase,Hiroyuki Keshi,Yoshinori Sakai,Atsushi Fukuoh,Takashi Sakamoto,Hiroyuki Itabe,Tatsuo Suzutani,Masahiro Ogasawara,Itsuro Yoshida,Nobutaka Wakamiya +13 more
TL;DR: It is found that CL-P1 can bind and phagocytose not only bacteria and Staphylococcus aureus but also yeast and it reacts with oxidized low density lipoprotein (OxLDL) but not with acetylated LDL (AcLDL).
228
Human mannan-binding lectin inhibits the infection of influenza A virus without complement
Tetsuo Kase,Yasuhiko Suzuki,Takao Kawai,Takashi Sakamoto,Katsuki Ohtani,Souji Eda,A Maeda,Y Okuno,Takashi Kurimura,Nobutaka Wakamiya +9 more
TL;DR: Lectin blot and immunohistochemistry assays showed that these antiviral activities involved binding between MBL and two viral envelope proteins, haemagglutinin and neuraminidase, suggesting that human MBL can play an important role in innate immunity by direct viral neutralization and inhibition of viral spread, as well as an indirect role through opsonization and complement activation.
122
Structure of a truncated human surfactant protein D is less effective in agglutinating bacteria than the native structure and fails to inhibit haemagglutination by influenza A virus.
Souji Eda,Yasuhiko Suzuki,Takao Kawai,Katsuki Ohtani,Tetsuo Kase,Yousuke Fujinaga,Takashi Sakamoto,Takashi Kurimura,Nobutaka Wakamiya +8 more
TL;DR: Results indicate that the agglutination activity of trimeric collectins can be largely retained, and furthermore that the oligomeric structure with several hands at opposite sites can enhance agglUTination activity.
High-level and effective production of human mannan-binding lectin (MBL) in Chinese hamster ovary (CHO) cells.
Katsuki Ohtani,Yasuhiko Suzuki,Souji Eda,Takao Kawai,Tetsuo Kase,Hiroyuki Keshi,Yoshinori Sakai,Satoshi Yamamoto,Takashi Sakamoto,Nobutaka Wakamiya +9 more
TL;DR: The recombinant human MBL has both sugar-binding and complement activation activity and, like native MBL, can inhibit hemagglutination of influenza A virus.
45
Recombinant bovine conglutinin, lacking the N-terminal and collagenous domains, has less conglutination activity but is able to inhibit haemagglutination by influenza A virus.
Souji Eda,Yasuhiko Suzuki,Tetsuo Kase,Takao Kawai,Katsuki Ohtani,Takashi Sakamoto,Takashi Kurimura,Nobutaka Wakamiya +7 more
TL;DR: The results suggest that in order for conglutinin to inhibit haemagglutination caused by the influenza virus, as well as to have sugar binding activity or to form trimers, it does not require the N-terminal and collagenous domains; however, they are essential for full conglUTination activity.