Søren Heissel
Rockefeller University
29 Papers
7 Citations
Søren Heissel is an academic researcher from Rockefeller University. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 3, co-authored 8 publications.
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Papers
Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers
Ayuko Hoshino,Ayuko Hoshino,Han Sang Kim,Han Sang Kim,Linda Bojmar,Linda Bojmar,Linda Bojmar,Kofi Ennu Gyan,Michele Cioffi,Jonathan M. Hernandez,Jonathan M. Hernandez,Jonathan M. Hernandez,Constantinos P. Zambirinis,Constantinos P. Zambirinis,Gonçalo Rodrigues,Gonçalo Rodrigues,Henrik Molina,Søren Heissel,Milica Tesic Mark,Loïc Steiner,Loïc Steiner,Alberto Benito-Martin,Serena Lucotti,Angela Di Giannatale,Katharine Offer,Miho Nakajima,Caitlin Williams,Laura Nogués,Laura Nogués,Fanny A. Pelissier Vatter,Ayako Hashimoto,Ayako Hashimoto,Ayako Hashimoto,Alexander E. Davies,Daniela Freitas,Daniela Freitas,Candia M. Kenific,Yonathan Ararso,Weston Buehring,Pernille Lauritzen,Yusuke Ogitani,Kei Sugiura,Kei Sugiura,Naoko Takahashi,Maša Alečković,Kayleen A. Bailey,Joshua S. Jolissant,Joshua S. Jolissant,Huajuan Wang,Ashton Harris,L. Miles Schaeffer,Guillermo García-Santos,Guillermo García-Santos,Zoe Posner,Vinod P. Balachandran,Yasmin Khakoo,G. Praveen Raju,Avigdor Scherz,Irit Sagi,Ruth Scherz-Shouval,Yosef Yarden,Moshe Oren,Mahathi Malladi,Mary Petriccione,Kevin C. De Braganca,Maria Donzelli,Cheryl Fischer,Stephanie Vitolano,Geraldine P. Wright,Lee Ganshaw,Mariel Marrano,Amina Ahmed,Joe DeStefano,Enrico Danzer,Michael H.A. Roehrl,Norman J. Lacayo,Theresa C. Vincent,Theresa C. Vincent,Martin R. Weiser,Mary S. Brady,Paul A. Meyers,Leonard H. Wexler,Srikanth R. Ambati,Alexander J. Chou,Emily K. Slotkin,Shakeel Modak,Stephen S. Roberts,Ellen M. Basu,Daniel Diolaiti,Benjamin A. Krantz,Benjamin A. Krantz,Fatima Cardoso,Amber L. Simpson,Michael F. Berger,Charles M. Rudin,Diane M. Simeone,Maneesh Jain,Cyrus M. Ghajar,Surinder K. Batra,Ben Z. Stanger,Jack D. Bui,Kristy A. Brown,Vinagolu K. Rajasekhar,John H. Healey,Maria de Sousa,Maria de Sousa,Kim Kramer,Sujit Sheth,Jeanine Baisch,Virginia Pascual,Todd E. Heaton,Michael P. La Quaglia,David J. Pisapia,Robert E. Schwartz,Haiying Zhang,Yuan Liu,Arti Shukla,Laurence Blavier,Yves A. DeClerck,Mark A. LaBarge,Mina J. Bissell,Thomas C. Caffrey,Paul M. Grandgenett,Michael A. Hollingsworth,Jacqueline Bromberg,Jacqueline Bromberg,Bruno Costa-Silva,Héctor Peinado,Yibin Kang,Benjamin A. Garcia,Eileen M. O'Reilly,David P. Kelsen,Tanya M. Trippett,David R. Jones,Irina Matei,William R. Jarnagin,David Lyden +136 more
TL;DR: EVP proteins can serve as reliable biomarkers for cancer detection and determining cancer type, and a panel of tumor-type-specific EVP proteins in TEs and plasma are defined, which can classify tumors of unknown primary origin.
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Structure of an endosomal signaling GPCR–G protein–β-arrestin megacomplex
Anthony H. Nguyen,Alex R.B. Thomsen,Alex R.B. Thomsen,Thomas J. Cahill,Rick Huang,Li-Yin Huang,Tara C. Marcink,Oliver B. Clarke,Søren Heissel,Ali Masoudi,Danya Ben-Hail,Fadi Samaan,Venkata P. Dandey,Yong Zi Tan,Chuan Hong,Jacob P. Mahoney,Jacob P. Mahoney,Sarah Triest,Sarah Triest,John Little,Xin Chen,Roger K. Sunahara,Roger K. Sunahara,Jan Steyaert,Henrik Molina,Zhiheng Yu,Amedee des Georges,Amedee des Georges,Robert J. Lefkowitz,Robert J. Lefkowitz +29 more
TL;DR: The cryo-EM structure of a megaplex between chimeric GPCR, G protein and β-arrestin in their canonical active conformations provides insight into the basis of sustained G protein signaling upon megacomplex internalization.
SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells.
Ying Wang,Frederick S. Yen,Xiphias Ge Zhu,Rebecca C. Timson,Ross A. Weber,Changrui Xing,Yuyang Liu,Benjamin Allwein,Hanzhi Luo,Hsi-Wen Yeh,Søren Heissel,Gokhan Unlu,Eric R. Gamazon,Eric R. Gamazon,Michael G. Kharas,Richard K Hite,Kıvanç Birsoy +16 more
TL;DR: In this article, the authors identify SLC25A39, a mitochondrial membrane carrier of unknown function, as a regulator of GSH transport into mitochondria, and show that loss of SLC 25A39 reduces mitochondrial GSH import and abundance without affecting cellular GSH levels.
136
Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells
Xiphias Ge Zhu,Aleksey Chudnovskiy,Lou Baudrier,Benjamin Prizer,Yuyang Liu,Benjamin N. Ostendorf,Norihiro Yamaguchi,Abolfozl Arab,Bernardo Tavora,Rebecca C. Timson,Søren Heissel,Elisa de Stanchina,Henrik Molina,Gabriel D. Victora,Hani Goodarzi,Kıvanç Birsoy +15 more
TL;DR: CRISPR screens in PDAC cells grown in culture or engrafted in immunocompetent mice provide metabolic dependencies arising from microenvironmental limitations and the immune system, nominating potential anti-cancer targets.
98
Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior.
Jennifer Blaze,Albertas Navickas,H. L. Phillips,Søren Heissel,A. Plaza-Jennings,Sohit Miglani,Hosseinali Asgharian,M. Foo,Christopher D. Katanski,C. P. Watkins,Zachary T. Pennington,Behnam Javidfar,Sergio Espeso-Gil,B. Rostandy,Hanan Alwaseem,C. G. Hahn,Henrik Molina,Denise J. Cai,Tao Pan,Wei-Dong Yao,Hani Goodarzi,Fatemeh Haghighi,Schahram Akbarian +22 more
TL;DR: In this article, the authors report bi-directional changes in depression-related behaviors after genetic disruption of neuronal tRNA cytosine methylation, including conditional ablation and transgene-derived overexpression of Nsun2 in the mouse prefrontal cortex (PFC).