Søren Dalager
Aarhus University Hospital
9 Papers
69 Citations
Søren Dalager is an academic researcher from Aarhus University Hospital. The author has contributed to research in topics: Cardiomyopathy & Sudden death. The author has an hindex of 6, co-authored 9 publications.
Chat about Author
Papers
Protein expression studies of desmoplakin mutations in cardiomyopathy patients reveal different molecular disease mechanisms
Torsten Bloch Rasmussen,Jens Jacob Hansen,Peter H. Nissen,Johan Palmfeldt,Søren Dalager,Uffe Birk Jensen,WY Kim,Lene Heickendorff,Henning Mølgaard,Henrik Jensen,Keld E. Sørensen,Ulrik Baandrup,Peter Bross,Jens Mogensen +13 more
TL;DR: The investigations revealed that the disease mechanisms varied accordingly to the specific types of DSP mutation identified and included haploinsufficiency, dominant‐negative effects, or a combination hereof, and suggested that the keratinocytes cultured from patients are a valuable and easily accessible resource to elucidate the effects of desmosomal gene mutations in humans.
36
Mutated desmoglein-2 proteins are incorporated into desmosomes and exhibit dominant-negative effects in arrhythmogenic right ventricular cardiomyopathy.
Torsten Bloch Rasmussen,Johan Palmfeldt,Peter H. Nissen,Raffaela Magnoni,Søren Dalager,Uffe Birk Jensen,Won Yong Kim,Lene Heickendorff,Henning Mølgaard,Henrik Jensen,Ulrik Baandrup,Peter Bross,Jens Mogensen,Jens Mogensen +13 more
TL;DR: Results indicated that ARVC caused by DSG2 mutations is often transmitted by recessive or digenic inheritance, and suggested a dominant‐negative effect of the mutatedDSG2 proteins because they were incorporated into the desmosomes.
34
Pregnancy associated plasma protein-A (PAPP-A) is not a marker of the vulnerable atherosclerotic plaque.
Kasper Iversen,Ane S. Teisner,Søren Dalager,Karen Ege Olsen,Charlotte Floridon,Børge Teisner +5 more
TL;DR: Elevation of Papp-A in patients with acute coronary syndromes seems to be caused by heparin induced release of PAPP-A from the arterial wall and not due to excretion from vulnerable plaques.
29
Large eccrine angiomatous hamartoma: a novel clinical presentation of disease.
TL;DR: A novel clinical presentation of eccrine angiomatous hamartoma: large, erythematous, and slightly indurated plaque localized on the upper back is described, emphasizing the role of histopathology in the diagnostic process and botulinum toxin as a viable treatment option.
Fatal giant cell myocarditis in a patient with multiple autoimmune disorders
Torsten Bloch Rasmussen,Søren Dalager,Niels Holmark Andersen,Troels Krarup Hansen,Jens Erik Nielsen-Kudsk +4 more
TL;DR: At 1-year follow-up the patient was in New York Heart Association (NYHA) class I, had episodes of sustained ventricular tachycardia but showed no evidence of GCM recurrence in endomyocardial biopsies.
6