Sönke Rehder
University of Hamburg
6 Papers
77 Citations
Sönke Rehder is an academic researcher from University of Hamburg. The author has contributed to research in topics: Cocrystal & Raman spectroscopy. The author has an hindex of 6, co-authored 6 publications. Previous affiliations of Sönke Rehder include University of Copenhagen & University of Otago.
Chat about Author
Papers
Investigation of the Formation Process of Two Piracetam Cocrystals during Grinding
Sönke Rehder,Marten Klukkert,Korbinian Löbmann,Clare J. Strachan,A. Sakmann,Keith C. Gordon,Thomas Rades,Claudia S. Leopold +7 more
TL;DR: It was shown that liquid-assisted grinding led to faster cocrystal formation than dry grinding, which may be explained by the higher transformation rate due to the presence of liquid.
62
High-shear granulation as a manufacturing method for cocrystal granules
Sönke Rehder,Niels Peter Aae Christensen,Jukka Rantanen,Thomas Rades,Thomas Rades,Claudia S. Leopold +5 more
TL;DR: It was concluded that high-shear wet granulation is a valuable, however complex, manufacturing method for cocrystals and should be investigated during pre-formulation.
33
Thermal degradation of amorphous glibenclamide.
TL;DR: The crystals formed during sublimation of amorphous glibenclamide do not represent a glibanclamide polymorph, but a thermal degradation product, namely 1,3-dicyclohexylurea, which may decompose to carbon monoxide and cyclohexylamine.
31
A case study of real-time monitoring of solid-state phase transformations in acoustically levitated particles using near infrared and Raman spectroscopy.
Sönke Rehder,Jian X. Wu,J. Laackmann,J. Laackmann,Hans-Ulrich Moritz,Jukka Rantanen,Thomas Rades,Thomas Rades,Claudia S. Leopold +8 more
TL;DR: It was concluded that acoustic levitation with NIR and Raman spectroscopy combined with multivariate curve resolution allowed direct determination of the recrystallisation kinetics of amorphous drugs and thus is a promising technique for monitoring solid-state phase transformations of adhesive small-sized samples during the early phase of drug development.
24
Chemical imaging and solid state analysis at compact surfaces using UV imaging
Jian X. Wu,Sönke Rehder,Frans van den Berg,José Manuel Amigo,Jens Michael Carstensen,Thomas Rades,Claudia S. Leopold,Jukka Rantanen +7 more
TL;DR: It is demonstrated that the multi-wavelength UV imaging is a fast process analytical technique with the potential for real-time monitoring of critical quality attributes and the critical evaluation of the mapping results and the selection of model parameters for the chemical mapping.
19