Sonja Scheffler
Humboldt University of Berlin
5 Papers
105 Citations
Sonja Scheffler is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Proteasome & Gene expression. The author has an hindex of 5, co-authored 5 publications.
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Papers
Autoantibodies in primary Sjögren's syndrome are directed against proteasomal subunits of the α and β type
Eugen Feist,Ulrike Kuckelkorn,Thomas Dörner,Helge Dönitz,Sonja Scheffler,Falk Hiepe,Peter-M. Kloetzel,Gerd-R. Burmester,Gerd-R. Burmester +8 more
TL;DR: The humoral antiproteasome response in primary SS, in contrast to its secondary form, is characterized by an extensive recognition pattern of several subunits, indicating a polyspecific B cell activation against the 20S proteasome.
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Diagnostic importance of anti-proteasome antibodies.
Eugen Feist,Thomas Dorner,Ulrike Kuckelkorn,Sonja Scheffler,Gerd-R. Burmester,Peter-M. Kloetzel +5 more
TL;DR: Recent data is summarized providing evidence that the 20S proteasome represents an important target of the humoral autoimmune response in systemic autoimmune diseases and extends insight into pathogenic aspects of these diseases.
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Expression of Proteasomal Immunosubunit ß1i Is Dysregulated in Inflammatory Infiltrates of Minor Salivary Glands in Sjögren’s Syndrome
L. Morawietz,Lorena Martinez-Gamboa,Sonja Scheffler,Gert Hausdorf,Anja Dankof,Ulrike Kuckelkorn,Thomas Doerner,Karl Egerer,Gerd-R. Burmester,Denise L. Faustman,Eugen Feist +10 more
TL;DR: The proteasomal ß1i subunit is dysregulated in peripheral white blood cells and in inflammatory infiltrates of minor salivary glands in patients with SS and patients with sicca syndrome.
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Gene expression of catalytic proteasome subunits and resistance toward proteasome inhibition of B lymphocytes from patients with primary sjogren syndrome.
Lorena Martinez-Gamboa,Karsten Lesemann,Ulrike Kuckelkorn,Sonja Scheffler,Khetam Ghannam,M. Hahne,Timo Gaber-Elsner,Karl Egerer,L. Naumann,Frank Buttgereit,Thomas Dorner,Peter M. Kloetzel,Gerd R Burmester,Denise L. Faustman,Eugen Feist +14 more
TL;DR: In pSS, catalytic subunits of the proteasome are upregulated at the mRNA level, while dysregulation of subunit β1i is attributed to B lymphocytes, supporting the novel notion that susceptibility depends on cellular intrinsic factors and on proteAsome activation.
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Prevalence of 20S proteasome, anti-nuclear and thyroid antibodies in young patients at onset of type 1 diabetes mellitus and the risk of autoimmune thyroiditis.
Olga Kordonouri,Kathrin Meyer,Karl Egerer,Reinhard Hartmann,Sonja Scheffler,Gerd-R. Burmester,Ulrike Kuckelkorn,Thomas Danne,Eugen Feist +8 more
TL;DR: Data underline that autoimmunity in patients with DM1 is not only restricted to beta-cell antigens at the onset of disease, and patients with positive thyroid and anti-nuclear antibodies are at high risk to develop autoimmune thyroiditis during the first 5 years of DM1.
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