N -(3-Silicapropyl)- N -methyl imidazolium hydrogen sulfate ([Sipmim]HSO 4 ) is prepared and employed as a recyclable catalyst for the synthesis of 4,4’-(arylmethylene)bis(1 H -pyrazol-5-ols) from aromatic aldehydes with 3-methyl-l-phenyl-5-pyrazolone in refluxing ethanol. [Sipmim]HSO 4 could be recycled for several times without any additional treatment.

/pdf/synthesis-of-4-4-arylmethylene-bis-1h-pyrazol-5-ols-using-2qssxay2wc.pdf

Synthesis of 4,4’-(Arylmethylene)bis(1H-pyrazol-5-ols) Using Silica-bonded Ionic Liquid as Recyclable Catalyst

A new and convenient method for the synthesis of bis(pyrazolyl)methanes by one-pot tandem Knoevenagel–Michael reaction of 3-methyl-1-phenyl-5-pyrazolone with aryl, heteroaryl, or alkyl aldehydes in...

2-Hydroxyethylammonium acetate as a reusable and cost-effective ionic liquid for the efficient synthesis of bis(pyrazolyl)methanes and 2-pyrazolyl-1-nitroalkanes

A rapid and efficient solvent-free microwave-assisted synthesis of pyrazolone derivatives containing substituted isoxazole ring

A visible light-promoted, efficient, green, and sustainable strategy has been adopted to unlatch a new pathway toward the synthesis of a library of medicinally important 4,4′-(arylmethylene)bis(1H-pyrazol-5-ols) moieties using substituted aromatic aldehydes and sterically hindered 3-methyl-1-phenyl-2-pyrazoline-5-one in excellent yield. This reaction shows high functional group tolerance and provides a cost-effective and catalyst-free protocol for the quick synthesis of biologically active compounds from readily available substrates. Synthesized compounds were characterized by spectroscopic techniques such as IR, 1HNMR, 13CNMR, and single-crystal XRD analysis. All the synthesized compounds were evaluated for their antiproliferative activities against a panel of five different human cancer cell lines and compared with Tamoxifen using MTT assay. Compound 3m exhibited maximum antiproliferative activity and was found to be more active as compared to Tamoxifen against both the MCF-7 and MDA-MB-231 cell lines with an IC50 of 5.45 and 9.47 μM, respectively. A molecular docking study with respect to COVID-19 main protease (Mpro) (PDB ID: 6LU7) has also been carried out which shows comparatively high binding affinity of compounds 3f and 3g (−8.3 and −8.8 Kcal/mole, respectively) than few reported drugs such as ritonavir, remdesivir, ribacvirin, favipiravir, hydroxychloroquine, chloroquine, and olsaltamivir. Hence, it reveals the possibility of these compounds to be used as effective COVID-19 inhibitors.

Visible Light-Promoted Green and Sustainable Approach for One-Pot Synthesis of 4,4’-(Arylmethylene)bis(1H-pyrazol-5-ols), In Vitro Anticancer Activity, and Molecular Docking with Covid-19 Mpro

FeSO4⋅7H2O Catalyzed Rapid and Efficient One‐Pot Multicomponent Synthesis of Functionalized Pyrazol‐yl‐pyrazolone Methanes

A new class of pyrazolone derivatives has been isolated in good to excellent yields from the 2:1 condensation reaction between 3-methyl-1-phenyl-5-pyrazolone and arylaldehydes in the presence of ionic liquid [HMIM]HSO4. The compounds were characterised by their IR, NMR spectra, MS and elemental analyses. The important features of the methodology are a wide application range of substrates, higher yields and shorter reaction time.

An Efficient One‐pot Synthesis of Pyrazolone Derivatives Promoted by Acidic Ionic Liquid

An Efficient One‐Pot Synthesis of Pyrazolone Derivatives Promoted by Acidic Ionic Liquid.

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An Efficient One‐pot Synthesis of Pyrazolone Derivatives Promoted by Acidic Ionic Liquid

An Efficient One‐Pot Synthesis of Pyrazolone Derivatives Promoted by Acidic Ionic Liquid.