22 Papers
14 Citations
Song Guo is an academic researcher from CAS-MPG Partner Institute for Computational Biology. The author has contributed to research in topics: Gene & Transcriptome. The author has an hindex of 14, co-authored 22 publications. Previous affiliations of Song Guo include Chinese Academy of Sciences & Skolkovo Institute of Science and Technology.
Chat about Author
Papers
Transcriptional neoteny in the human brain
Mehmet Somel,Henriette Franz,Zheng Yan,Anna Lorenc,Song Guo,Thomas Giger,Janet Kelso,Birgit Nickel,Michael Dannemann,Sabine Bahn,Maree J. Webster,Cynthia Shannon Weickert,Michael Lachmann,Svante Pääbo,Philipp Khaitovich +14 more
TL;DR: It is shown that the brain transcriptome is dramatically remodeled during postnatal development and that developmental changes in the human brain are indeed delayed relative to other primates.
Estimating accuracy of RNA-Seq and microarrays with proteomics.
Xing Fu,Ning Fu,Song Guo,Zheng Yan,Ying Xu,Hao Hu,Hao Hu,Corinna Menzel,Wei Chen,Yixue Li,Rong Zeng,Philipp Khaitovich,Philipp Khaitovich +12 more
TL;DR: This study evaluates relative accuracy of microarrays and transcriptome sequencing (RNA-Seq) using third methodology: proteomics to find that RNA-Sequ provides a better estimate of absolute expression levels.
MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain
Mehmet Somel,Song Guo,Ning Fu,Zheng Yan,Haiyang Hu,Ying Xu,Yuan Yuan,Zhibin Ning,Yuhui Hu,Corinna Menzel,Hao Hu,Michael Lachmann,Rong Zeng,Wei Chen,Philipp Khaitovich +14 more
TL;DR: Surprisingly, many gene expression changes previously attributed to aging, such as down-regulation of neural genes, initiate in early childhood, suggesting a direct link between developmental regulation and expression changes taking place in aging.
Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques
Xiling Liu,Mehmet Somel,Mehmet Somel,Lin Tang,Zheng Yan,Xi Jiang,Song Guo,Yuan Yuan,Liu He,Anna Oleksiak,Yan Zhang,Na Li,Yuhui Hu,Wei Chen,Zilong Qiu,Svante Pääbo,Philipp Khaitovich,Philipp Khaitovich +17 more
TL;DR: It is shown that the most prominent human-specific expression change affects genes associated with synaptic functions and represents an extreme shift in the timing of synaptic development in the prefrontal cortex, but not the cerebellum.
MicroRNA-Driven Developmental Remodeling in the Brain Distinguishes Humans from Other Primates
Mehmet Somel,Xiling Liu,Lin Tang,Zheng Yan,Haiyang Hu,Song Guo,Xi Jiang,Xiaoyu Zhang,Guohua Xu,Gangcai Xie,Gangcai Xie,Na Li,Yuhui Hu,Wei Chen,Wei Chen,Svante Pääbo,Philipp Khaitovich +16 more
TL;DR: Comparison of human, chimpanzee, and macaque brain transcriptomes reveals a significant developmental remodeling in the human prefrontal cortex, potentially shaped by microRNA.
233