Objective: To synthesize a series of (-) S & (+) S oxadiazole derivatives by the reaction of (-) (2S)-2-amino-2-(2-chlorophenyl) acetohydrazide & (+) (2S)-2-amino-2-(2-chloro phenyl) acetohydrazide with con. H 2SO 4, L(+) Tartaric acid, L(-) Tartaric acid, Hydrazine Hydrate, POCl 3 Methods: The structures of novel synthesized compounds have been established on the basis of elemental analysis, IR, and Various aromatic acid respectively.

COMPARATIVE STUDIES OF NOVEL OXADIAZOLE DERIVATIVE HAVING CHIRAL CENTER AND THEIR ANTI-MICROBIAL ACTIVITIES Original Article

The aim of this work is to establish developed and validated method for the pharmaceutical analysis of Felodipine in bulk and pharmaceutical formulation by High Performance Thin Layer Chromatography HPTLC (NP) and Reverse Phase-High Performance Thin Layer Chromatography RP-HPTLC (RP). Chromatographic separation was performed on Pre-coated aluminum plates with 250 μm layer of Silica gel 60 F254 and Silica gel 60 RP-18 TLC F254S using Toluene: Methanol (8:2 v/v) and acetonitrile: water: glacial acetic acid (8:2:1 v/v/v) as a mobile phase, respectively. Scanning was carried out densitometrically at 237 nm. The Rf value of Felodipine in NP and RP were 0.40 and 0.53 and the reliability of the method was assessed by the evaluation of linearity which was found to be 300-1800 and 500-3000 ng/band with the r2 =0.998 correlation coefficient along with the accuracy of the method in terms of % recovery was found to be from 98-101 ± 1.04 % and 99-100 ± 0.47 % and the limit of detection and quantification were 11.51, 34.90 and 29.90, 90.61, respectively. The method can be used for routine analysis of Felodipine in bulk and pharmaceutical formulation.

/pdf/hptlc-and-rp-hptlc-method-development-and-validation-for-the-1vqveb17ds.pdf

HPTLC and RP-HPTLC Method Development and Validation for the Estimation of Felodipine in Bulk and Pharmaceutical Formulation

The structure of the oxadiazole skeleton is a biologically and biochemically active nucleus that has a multiple number of biological activities. The oxadiazole structure is a five-membered aromatic ring that has been used in numerous studies and molecules synthesised in laboratories. The principle structure of the Oxadiazole ring with a pair of Pyridine-type nitrogen atoms has been confirmed to be valuable for Oxadiazole analogues for having efficacious protein interactions with a large number of enzyme proteins and receptor proteins present in the organ system of the human body through different types of interactions, like Vander Wall interactions, thereby producing a huge variety of biological activities or pharmacological properties. Due to the variety in the pharmacological activity of Oxadiazole and their derivatives and analogues, they have been termed as one of the important pharmacological aspects to study. Multiple numbers of oxadiazole related synthetic compounds possessing high potent action and therapeutic activity are being widely incorporated for treatment and management of multiple diseases and disorders, giving immeasurable progression and establishment value. Oxadiazole derivatives express a multiple number of pharmacological activities like antimicrobial, anti-inflammatory, analgesic, antifungal, antipyretic, antidepressant, anti-tubercular, anticonvulsant, anticholinesterase, antihypertensive, antidiabetic, antitumor/anticancer, anti-HIV, antioxidant, etc. The history of 1,3,4-Oxadiazole is also very interesting. It shows that it attracted many chemists, researchers, and scientists to explore the Oxadiazole nucleus as a biologically active molecule having promising potency. This review article mainly focuses on the pharmacological profile of 1,3,4-Oxadiazole with various activities and examples (in the form of figures and structures). Expectations are that this article will be like a path showing torch to help and serve as guidance for new innovations/ideas along the progression of research for the evolution of more active/potent and less poisonous/toxic Oxadiazole-based derivatives.

/pdf/a-review-on-oxadiazoles-as-a-pharmacologically-active-26tlh40d.pdf

A Review on Oxadiazoles as a Pharmacologically Active Nucleus

A series of novel 2,5-diaryloxadiazole (III) and mercaptooxadiazole derivatives (VIII) are synthesized, which show promising antibacterial, antifungal and antitubercular activities.

Synthesis, Antimicrobial and Antitubercular Activity of Some Novel [3‐Isonicotinoyl‐5‐(4‐substituted)‐2,3‐dihydro‐1,3,4‐oxadiazol‐2‐yl] and Substituted 5‐(Pyridin‐4‐yl)‐1,3,4‐oxadiazole‐2‐thiol Derivatives.

The main objective of the proposed methods is to disclose simple, accurate, precise, reproducible and sensitive UV-spectrophotometry methods for the estimation of Felodipine in Bulk and in-house formulation tablets. Further, this study is designed to validate the developed methods as per ICH guidelines. Felodipine is a long acting calcium channel blocker anti-hypertensive agent. Four simple UVSpectrophotometric methods were established by using Double beam UV-Spectrophotometer (UV-2450, Shimadzu), Felodipine showed maximum absorbance at 237.60 nm (λ max). The calibration curves were plotted in the concentration range of 03-18 μg/mL. The % recovery was found to be in the range of 99-101%. The precision of the proposed method was calculated in terms of %RSD <2, methods are rugged and precise. Proposed methods can be used for routine analysis of Felodipine in bulk and in-house formulations.

Quantitative Estimation of Felodipine by Zero and First Order Derivative Area under Curve Spectrophotometric Methods in Bulk and in-house Tablets

/pdf/synthesis-antimicrobial-and-antitubercular-activity-of-some-vmhus7h8jn.pdf

Synthesis, antimicrobial and antitubercular activity of some novel [3-isonicotinoyl-5-(4-substituted)-2,3-dihydro-1,3,4-oxadiazol-2-yl] and substituted 5-(pyridin-4-yl)-1,3,4-oxadiazole-2-thiol derivatives

The process related impurity of Felodipine i.e: Diethyl-4 (2-chlorophenyl) 2,6 dimethyl-1,4-dihydro pyridine 3,5 dicarboxylate was synthesized , characterized and quantified in bulk and formulation. The synthesis of intermediate was carried out by Hantzch process using O-chlorobenzaldehyde, ethylacetoacetate, in presence of ammonia and methanol as a catalyst. The percentage yield was found to be 78 %. Recrystallization and purification of FI was done. The preliminary evaluation was done on laboratory scale via melting point, elemental analysis and TLC. The melting point of impurity was found to be 136-140 0 C. The TLC of impurity was carried by using Benzene: Methanol (6:1) and the R f was found to be 0.64.The regioisomeric impurity was synthesized, purified, and characterized by IR, NMR and UV method was developed for quantification of synthesized impurity. The method was validated as per ICH Q2B guidelines. The UV method was found to be linear, precise, accurate, robust and rugged. Finally Diethyl-4 (2-chlorophenyl) 2,6 dimethyl-1,4-dihydro pyridine 3,5 dicarboxylate impurity was quantified from Felodipine bulk and its marketed tablet formulation.

Development and validation of UV spectrophotometric method for estimation of regioisomeric impurity in Felodipine bulk and formulation

Summary The neuraminidase inhibitors are act by blocking activity of viral neuraminidase enzyme & prevents particles released from infected cells. Various neuraminidase inhibitors are used for antiviral acyivity & also these agents sare used in the treatment of influenza & swine flu. The present review deals with study of pharmacology, pharmacokinetics, efficacy, and safety of Zanamivir and Oseltamivir for the prophylaxis and treatment of influenza.

/pdf/euramiidase-ihibitors-aspromisig-h-11-ativiral-aget-3uc9sei86p.pdf

Euramiidase ihibitors aspromisig h 11 ativiral aget

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

Sonali Pawar

Author Tools

Chat about Author

Papers

Synthesis, antimicrobial and antitubercular activity of some novel [3-isonicotinoyl-5-(4-substituted)-2,3-dihydro-1,3,4-oxadiazol-2-yl] and substituted 5-(pyridin-4-yl)-1,3,4-oxadiazole-2-thiol derivatives

Development and validation of UV spectrophotometric method for estimation of regioisomeric impurity in Felodipine bulk and formulation

Synthesis, Antimicrobial and Antitubercular Activity of Some Novel [3‐Isonicotinoyl‐5‐(4‐substituted)‐2,3‐dihydro‐1,3,4‐oxadiazol‐2‐yl] and Substituted 5‐(Pyridin‐4‐yl)‐1,3,4‐oxadiazole‐2‐thiol Derivatives.

Euramiidase ihibitors aspromisig h 11 ativiral aget