Son B. Le
Mayo Clinic
7 Papers
55 Citations
Son B. Le is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 4, co-authored 4 publications.
Chat about Author
Papers
Inhibition of Mitochondrial Respiration as a Source of Adaphostin-Induced Reactive Oxygen Species and Cytotoxicity*
Son B. Le,M. Katie Hailer,Sarah A. Buhrow,Qi Wang,Karen S. Flatten,Peter Pediaditakis,Keith C. Bible,Lionel D. Lewis,Edward A. Sausville,Yuan Ping Pang,Matthew M. Ames,John J. Lemasters,Ekhson Holmuhamedov,Scott H. Kaufmann +13 more
TL;DR: In this paper, the authors investigated the source of reactive oxygen species (ROS) generated by adaphostin under aqueous conditions, and found that the highest concentration of adhostin was found in mitochondria.
79
Involvement of reactive oxygen species in adaphostin-induced cytotoxicity in human leukemia cells
Joya Chandra,Jennifer S. Hackbarth,Son B. Le,David A. Loegering,Nancy D. Bone,Laura M. Bruzek,Ven L. Narayanan,Alex A. Adjei,Neil E. Kay,Ayalew Tefferi,Judith E. Karp,Edward A. Sausville,Scott H. Kaufmann +12 more
TL;DR: Results indicate that this novel agent might have a broader spectrum of activity than originally envisioned, and outline a mechanism by which adaphostin can damage both myeloid and lymphoid leukemia cells.
71
Active oral regimen for elderly adults with newly diagnosed acute myelogenous leukemia: a preclinical and phase 1 trial of the farnesyltransferase inhibitor tipifarnib (R115777, Zarnestra) combined with etoposide
Judith E. Karp,Karen S. Flatten,Eric J. Feldman,Jacqueline Greer,David A. Loegering,Rebecca M. Ricklis,Lawrence E. Morris,Ellen K. Ritchie,B. Douglas Smith,Valerie Ironside,Timothy Talbott,Gail J. Roboz,Son B. Le,Xue Wei Meng,Paula A. Schneider,Nga T. Dai,Alex A. Adjei,Steven D. Gore,Mark J. Levis,John J. Wright,Elizabeth Garrett-Mayer,Scott H. Kaufmann +21 more
TL;DR: A phase-1 trial of tipifarnib plus etoposide in adults over 70 years of age who were not candidates for conventional induction chemotherapy was conducted in this article.
59
Adaphostin and other anticancer drugs quench the fluorescence of mitochondrial potential probes
Son B. Le,Ekhson Holmuhamedov,Ekhson Holmuhamedov,Ven L. Narayanan,Edward A. Sausville,Scott H. Kaufmann +5 more
TL;DR: The results indicate the need for caution when mitochondrial dyes are utilized to examine the effects of xenobiotics on ΔΨm and suggest that some previously reported direct effects of anticancer drugs on mitochondria might need re-evaluation.
Active oral regimen for elderly adults with newly diagnosed acute myelogenous leukemia: a preclinical and phase 1 trial of the farnesyltransferase inhibitor tipifarnib (R115777, Zarnestra) combined with etoposide.
Judith E. Karp,Karen S. Flatten,Eric J. Feldman,J. Greer,D. Loegering,Rebecca M. Ricklis,Lawrence E. Morris,Ellen K. Ritchie,B. D. Smith,Valerie Ironside,Timothy Talbott,Gail J. Roboz,Son B. Le,Xue Wei Meng,Paula A. Schneider,Nga T. Dai,Alex A. Adjei,Steven D. Gore,Mark J. Levis,John J. Wright,Elizabeth Garrett-Mayer,Scott H. Kaufmann +21 more
13