Somdatta Das
Gauhati University
8 Papers
15 Citations
Somdatta Das is an academic researcher from Gauhati University. The author has contributed to research in topics: HLA-DRB1 & Medicine. The author has an hindex of 3, co-authored 8 publications.
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Papers
MTHFR (C677T) polymorphism and PR (PROGINS) mutation as genetic factors for preterm delivery, fetal death and low birth weight: A Northeast Indian population based study.
TL;DR: MTHFR C677T may be used as a prognostic marker to stratify subpopulation of pregnancy cases predisposed to PTD; thereby controlling the risks associated with PTD.
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Associative role of HLA-DRB1 SNP genotypes as risk factors for susceptibility and severity of rheumatoid arthritis: A North-east Indian population-based study.
TL;DR: HLA‐DRB1 rs13192471 SNP plays a critical role in RA susceptibility and severity in North‐east Indian cases and has prognostic significance in RA.
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Impact of TNF-α profile in recurrent pregnancy loss pathogenesis: A patient based study from Assam.
Anjuma Begum,Archana Mishra,C. Das,Somdatta Das,Ratul Dutta,Natasha Kashyap,Purabi Deka Bose,Sujoy Bose +7 more
TL;DR: In this article, the significance of TNF-α profile in RPL pathogenesis in an ethnically distinct population from Assam, India was appraised, and a significant gestation specific increase in serum TNFα levels was observed in medically terminated pregnancy (MTP) and RPL cases (based on ASRM criteria) were enrolled with no anatomical and chromosomal abnormalities or pathological infections; and blood and/or placenta/product of conceptus (POC) tissue samples were collected with informed consent.
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•Journal Article
Genetic and expression changes in TNF-α as a risk factor for rheumatoid arthritis pathogenesis in northeast India.
TL;DR: The presence of –308 variant genotype is associated with increased risk of RA susceptibility and differential TNF-α expression, and has prognostic significance, which makes them suitable subjects for anti-TNF-}\upalpha therapy.
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