Soghra Fatima
University of Tennessee Health Science Center
7 Papers
109 Citations
Soghra Fatima is an academic researcher from University of Tennessee Health Science Center. The author has contributed to research in topics: Vascular smooth muscle & MAPK/ERK pathway. The author has an hindex of 7, co-authored 7 publications.
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Papers
20-Hydroxyeicosatetraenoic acid mediates calcium/calmodulin-dependent protein kinase II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells.
M. M. Muthalif,Ibrahim F. Benter,Nour A. Karzoun,Soghra Fatima,Jason L. Harper,Mohammed R. Uddin,Kafait U. Malik +6 more
TL;DR: Data suggest that activation of MAPK by NE, Ang II, and EGF is mediated by a signaling mechanism involving 20-HETE, which is generated by stimulation of cPLA2 by CaMKII, which may play a central role in the regulation of other cellular signaling molecules involved in cell proliferation and growth.
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The Oxidized Lipid and Lipoxygenase Product 12(S)-Hydroxyeicosatetraenoic Acid Induces Hypertrophy and Fibronectin Transcription in Vascular Smooth Muscle Cells via p38 MAPK and cAMP Response Element-binding Protein Activation MEDIATION OF ANGIOTENSIN II EFFECTS
Marpadga A. Reddy,Pushpa-Rekha Thimmalapura,Linda Lanting,Jerry L. Nadler,Soghra Fatima,Rama Natarajan +5 more
TL;DR: Results show for the first time that oxidized lipids such as 12(S)-HETE can induce VSMC growth and matrix gene expression and mediate growth factor effects via activation of the Ras-MAPK pathway and key target transcription factors.
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•Journal Article
Alpha-1A Adrenergic Receptor Stimulation with Phenylephrine Promotes Arachidonic Acid Release by Activation of Phospholipase D in Rat-1 Fibroblasts: Inhibition by Protein Kinase A
TL;DR: CAMP generated by alpha-1A AR stimulation acts as an inhibitory modulator of PLD activity and AA release via protein kinase A via PLD activation and cAMP accumulation, suggesting that the alpha- 1A, alpha-2B and alpha-3D ARs are coupled to PLDactivation and camp accumulation.
66
•Journal Article
Cytosolic phospholipase A2 activation by the p38 kinase inhibitor SB203580 in rabbit aortic smooth muscle cells.
TL;DR: It is reported that SB203580, which blocked p38 kinase activation elicited by anisomycin, increased the phosphorylation and activity of cytosolic phospholipase A2 (cPLA2) and arachidonic acid (AA) release in quiescent vascular smooth muscle cells from rabbit aortae and by interacting with calmodulin, activates CaMKII and cPLA2 and releases AA.
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Small GTP binding protein Ras contributes to norepinephrine-induced mitogenesis of vascular smooth muscle cells.
Mubarack M. Muthalif,Mohammed R. Uddin,Soghra Fatima,Jean-Hugues Parmentier,Zinat Khandekar,Kafait U. Malik +5 more
TL;DR: The data suggest that VSMC proliferation induced by norepinephrine and 20-HETE is mediated by Ras/MAP kinase pathway.
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