Sofie Vandevyver
Ghent University
18 Papers
6 Citations
Sofie Vandevyver is an academic researcher from Ghent University. The author has contributed to research in topics: Glucocorticoid receptor & Tumor necrosis factor alpha. The author has an hindex of 13, co-authored 18 publications. Previous affiliations of Sofie Vandevyver include Flanders Institute for Biotechnology.
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Papers
New Insights into the Anti-inflammatory Mechanisms of Glucocorticoids: An Emerging Role for Glucocorticoid-Receptor-Mediated Transactivation
TL;DR: The contribution of various GR dimer-inducible anti-inflammatory genes are summarized and the use of selective GR agonists as therapeutic agents is questioned.
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Comprehensive Overview of the Structure and Regulation of the Glucocorticoid Receptor
TL;DR: This review summarizes recent knowledge on the distinct GR isoforms and the processes that generate them and discusses the crucial role of the putative GR-bound DNA sequence as an allosteric ligand influencing GR structure and activity.
245
On the trail of the glucocorticoid receptor: into the nucleus and back.
TL;DR: The contribution of various chaperone components involved in the nuclear transport of GR are summarized, an updated model of its nuclear import and export is proposed and the importance of ligand‐independent nuclear transport is reviewed.
220
Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation
Sofie Vandevyver,Lien Dejager,Tom Van Bogaert,Anna Kleyman,Yusen Liu,Jan Tuckermann,Claude Libert +6 more
TL;DR: The data show that GR dimerization inhibits JNK2 through MKP1 and protects from TNF-induced apoptosis and lethal inflammation, identifying J NK2 as an essential player in inflammation induced by TNF.
131
Neutralizing TNFα restores glucocorticoid sensitivity in a mouse model of neutrophilic airway inflammation
Lien Dejager,Karen Dendoncker,Mieke Eggermont,Jolien Souffriau,F. Van Hauwermeiren,Monique Willart,E. Van Wonterghem,Thomas Naessens,Marlies Ballegeer,Sofie Vandevyver,Hamida Hammad,Bart N. Lambrecht,Bart N. Lambrecht,K. De Bosscher,Johan Grooten,Claude Libert +15 more
TL;DR: It is demonstrated that TNFα reduces the responsiveness to GCs in a mouse model of neutrophilic airway inflammation, demonstrating that antagonizing TNF α may offer a new strategy for therapeutic intervention in GC-resistant asthma.
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