Sofie Mellberg
Uppsala University
7 Papers
24 Citations
Sofie Mellberg is an academic researcher from Uppsala University. The author has contributed to research in topics: Angiogenesis & Endothelial stem cell. The author has an hindex of 6, co-authored 7 publications.
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Papers
Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGFβ2 in vascular abnormalization
Lothar C. Dieterich,Sofie Mellberg,Elise Langenkamp,Lei Zhang,Agata Zieba,Henriikka Salomäki,Martin Teichert,Martin Teichert,Hua Huang,Per Henrik Edqvist,Theo F. J. Kraus,Hellmut G. Augustin,Hellmut G. Augustin,Tommie Olofsson,Erik G. Larsson,Ola Söderberg,Grietje Molema,Fredrik Pontén,Patrik Georgii-Hemming,Irina Alafuzoff,Anna Dimberg +20 more
TL;DR: The transcriptome of tumour‐associated blood vessels is characterized and a gene signature clearly associated with pleomorphic, pathologically altered vessels in human glioblastoma (grade IV glioma) is described, suggesting that, in addition to VEGF‐A, TGFβ2 may represent a new target for vascular normalization therapy.
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VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation
Makoto Hayashi,Arindam Majumdar,Arindam Majumdar,Xiujuan Li,Jeremy Adler,Zuyue Sun,Simona Vertuani,Carina Hellberg,Sofie Mellberg,Sina Koch,Anna Dimberg,Gou Young Koh,Elisabetta Dejana,Heinz-Georg Belting,Markus Affolter,Gavin Thurston,Lars Holmgren,Dietmar Vestweber,Lena Claesson-Welsh +18 more
TL;DR: It is concluded that the role of Tie2 in maintenance of vascular quiescence involves VE-PTP-dependent dephosphorylation of VEGF receptor-2, and that VEGE-cadherin tyrosine phosphorylation, endothelial cell polarity and lumen formation is regulated.
Endocan is a VEGF-A and PI3K regulated gene with increased expression in human renal cancer.
Emma Rennel,Sofie Mellberg,Anna Dimberg,Ludvig Petersson,Johan Botling,Adam Ameur,Jakub Orzechowski Westholm,Jan Komorowski,Philippe Lassalle,Michael J. Cross,Pär Gerwins,Pär Gerwins +11 more
TL;DR: It is shown that, among angiogenic growth factors, VEGF-A is a specific inducer of endocan transcription which is translated into increased protein levels in VEGf-A treated endothelial cells.
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Analysis of VEGF--a regulated gene expression in endothelial cells to identify genes linked to angiogenesis.
TL;DR: Across endothelial cell lines, it was found that a significant fraction of these proteins had highly perturbed gene expression during angiogenesis, providing additional evidence for the role of endothelial cells in Alzheimer's disease.