Sofie Lundgren
University of Helsinki
17 Papers
8 Citations
Sofie Lundgren is an academic researcher from University of Helsinki. The author has contributed to research in topics: Biology & Somatic cell. The author has an hindex of 4, co-authored 11 publications.
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Papers
Clonal hematopoiesis in patients with rheumatoid arthritis.
Paula Savola,Sofie Lundgren,Mikko A. I. Keränen,Henrikki Almusa,Pekka Ellonen,Marjatta Leirisalo-Repo,Tiina Kelkka,Satu Mustjoki +7 more
TL;DR: It is hypothesized that CH may modulate chronic inflammation or disease activity in RA, and mutation findings with clinical parameters were compared to investigate associations between CH and the clinical phenotype in RA.
Somatic mutations in lymphocytes in patients with immune-mediated aplastic anemia.
Sofie Lundgren,Mikko A. I. Keränen,Matti Kankainen,Jani Huuhtanen,Jani Huuhtanen,Gunilla Walldin,Cassandra M Kerr,Michael J. Clemente,Freja Ebeling,Hanna Rajala,Oscar Brück,Harri Lähdesmäki,Sari Hannula,Tiina Hannunen,Pekka Ellonen,Neal S. Young,Seishi Ogawa,Jaroslaw P. Maciejewski,Eva Hellström-Lindberg,Satu Mustjoki,Satu Mustjoki +20 more
TL;DR: The prevalence and functional impact of somatic mutations in non-leukemic T cells is not well characterized, although clonal T-cell expansions are common as mentioned in this paper, and the effect of mutations in T cells on the pathogenesis of immune-mediated aplastic anemia (AA) has not been well characterized.
Somatic mutations and T-cell clonality in patients with immunodeficiency.
Paula Savola,Timi Martelius,Matti Kankainen,Jani Huuhtanen,Sofie Lundgren,Yrjö Koski,Samuli Eldfors,Tiina Kelkka,Mikko A. I. Keränen,Pekka Ellonen,Panu E. Kovanen,Soili Kytölä,Janna Saarela,Harri Lähdesmäki,Mikko Seppänen,Satu Mustjoki +15 more
TL;DR: Somatic mutations in genes implicated for autoimmunity and lymphoproliferation are common in CD4+ and CD8+ cells of patients with immunodeficiency, and may contribute to immune dysregulation in a subset of immunodficiency patients.
High prevalence of low-allele-fraction somatic mutations in STAT3 in peripheral blood CD8+ cells in multiple sclerosis patients and controls
Miko Valori,Joonas Lehikoinen,Lilja Jansson,Jonna Clancy,Sofie Lundgren,Satu Mustjoki,Pentti J. Tienari +6 more
TL;DR: In this paper , a set of 94 multiple sclerosis (MS) patients and 99 matched controls were analyzed using the Illumina MiSeq instrument with 2x300bp reads and 64 mutations were detected in the STAT3 SH2 domain.
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Next-Generation Sequencing Reveals a T Cell Receptor Signature Characteristic of Patients with Aplastic Anemia
Sofie Lundgren,Jani Huuhtanen,Mikko A. I. Keränen,Cassandra M. Hirsch,Emmi Jokinen,Markus Heinonen,Markus Heinonen,Paula Savola,Tiina Kelkka,Tiina Kelkka,Freja Ebeling,Jaroslaw P. Maciejewski,Eva Hellström-Lindberg,Harri Lähdesmäki,Satu Mustjoki +14 more
TL;DR: Interestingly, it is discovered that the public response (CTL clones that are statistically enriched in AA patients compared to healthy controls) could discriminate AA from healthy TCR repertoire, and this compartment could explain the variation in treatment responses and disease severity across patients.
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