Sofie Dekimpe
Flanders Institute for Biotechnology
2 Papers
Sofie Dekimpe is an academic researcher from Flanders Institute for Biotechnology. The author has contributed to research in topics: Gene & Chemistry. The author has an hindex of 1, co-authored 1 publications. Previous affiliations of Sofie Dekimpe include Katholieke Universiteit Leuven.
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Papers
Beyond peptide bond formation: the versatile role of condensation domains in natural product biosynthesis
TL;DR: A comprehensive overview of the multifaceted role of C domains in the biosynthesis of specialized metabolites in bacteria and fungi is presented and different perspectives are offered on how the exceptional functional versatility of C domain may be exploited for bioengineering approaches to expand the chemical diversity of nonribosomal peptides and other natural products.
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Polyketide Synthase-Mediated O-Methyloxime Formation in the Biosynthesis of the Oximidine Anti-cancer Agents.
Dries De Ruysscher,Angus N M Weir,Sofie Dekimpe,Geert Steurs,Ahmed El shemy,Leentje Persoons,Christopher B. Williams,Dirk Daelemans,Matthew P. Crump,Arnout Voet,Wim M. De Borggraeve,Eveline Lescrinier,Joleen Masschelein +12 more
TL;DR: In this article , the authors used a combination of in vivo, in vitro and computational approaches to identify the oximidine gene cluster in Pseudomonas baetica and the characterization of four novel oxIMidine variants, including a structurally simpler intermediate.
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