Sofie Celen
Rega Institute for Medical Research
9 Papers
41 Citations
Sofie Celen is an academic researcher from Rega Institute for Medical Research. The author has contributed to research in topics: Bicyclic molecule & Thymidine kinase. The author has an hindex of 4, co-authored 9 publications.
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Papers
Phosphodiesterase 10A PET Tracer: Kinetic Modeling and Test-Retest Study in Human Brain
Koen Van Laere,Rawaha Ahmad,Hendra Hudyana,Kristof Dubois,Mark E. Schmidt,Sofie Celen,Guy Bormans,Michel Koole +7 more
- 01 Jan 2013
TL;DR: Kinetic modeling of 18F-JNJ-42259152 shows that PDE10A activity can be reliably quantified and simplified using a reference tissue model with the frontal cortex as reference and a 60-min acquisition period.
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Synthesis and preliminary evaluation of 18F- or 11C-labeled bicyclic nucleoside analogues as potential probes for imaging varicella-zoster virus thymidine kinase gene expression using positron emission tomography.
Satish K. Chitneni,Christophe Deroose,Jan Balzarini,Rik Gijsbers,Sofie Celen,Tjibbe de Groot,Zeger Debyser,Luc Mortelmans,and Alfons M. Verbruggen,Guy Bormans +9 more
TL;DR: Two radiolabeled bicyclic nucleoside analogues were synthesized and evaluated as PET reporter probes for varicella-zoster virus thymidine kinase (VZV-tk) gene expression imaging in brain and RP-HPLC analysis of plasma and urine samples of mice injected with [11C]-3 revealed that this tracer is very stable in vivo.
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Patent
Radiolabelled pde10 ligands
Jose Ignacio Andres-Gil,Meri De Angelis,Guy Bormans,Sofie Celen +3 more
- 27 Oct 2010
TL;DR: In this article, a radio labelled PDE10 ligand was used for imaging and quantifying the enzyme in tissues, using positron-emission tomography (PET), and compositions comprising such compounds, processes for preparing such compounds and compositions, and the use of such compounds for imaging a tissue, cells or a host, in vitro or in vivo.
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A p-[18F]fluoroethoxyphenyl bicyclic nucleoside analogue as a potential positron emission tomography imaging agent for varicella-zoster virus thymidine kinase gene expression.
Satish K. Chitneni,Christophe Deroose,Jan Balzarini,Rik Gijsbers,Sofie Celen,Zeger Debyser,Luc Mortelmans,Alfons Verbruggen,Guy Bormans +8 more
TL;DR: The synthesis and evaluation of p-alkoxyphenyl-BCNA tracers are reported, which are found to be superior to the m-alkylating agents and higher uptake into VZV-tk gene-transduced cells compared to control cells.
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