Sofia Rahman
UCL Institute of Child Health
14 Papers
34 Citations
Sofia Rahman is an academic researcher from UCL Institute of Child Health. The author has contributed to research in topics: Congenital hyperinsulinism & Insulin. The author has an hindex of 7, co-authored 14 publications.
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Papers
A link between FTO, ghrelin, and impaired brain food-cue responsivity
Efthimia Karra,Owen O'Daly,Agharul I. Choudhury,Ahmed Yousseif,Steven Millership,Marianne T. Neary,William R. Scott,Keval Chandarana,Sean Manning,Martin E. Hess,Hiroshi Iwakura,Takashi Akamizu,Queensta Millet,Cigdem Gelegen,Megan E. Drew,Sofia Rahman,Julian J. Emmanuel,Steven Williams,Ulrich Rüther,Jens C. Brüning,Dominic J. Withers,Fernando Zelaya,Rachel L. Batterham +22 more
TL;DR: Functional MRI in normal-weight AA and TT humans found that the FTO genotype modulates the neural responses to food images in homeostatic and brain reward regions, and shows that FTO regulates ghrelin, a key mediator of ingestive behavior.
Molecular mechanisms of congenital hyperinsulinism
TL;DR: An update on the molecular basis of CHI is provided, which shows that genetic abnormalities in HNF4A and HNF1A lead to a dual phenotype of HH in the newborn period and maturity onset-diabetes later in life.
Hyperinsulinemic hypoglycemia in children and adolescents: Recent advances in understanding of pathophysiology and management
Maria Gϋemes,Maria Gϋemes,Sofia Rahman,Ritika R. Kapoor,Sarah E. Flanagan,Jayne A L Houghton,Shivani Misra,Nick Oliver,Mehul T. Dattani,Mehul T. Dattani,Pratik Shah,Pratik Shah +11 more
TL;DR: Rapid diagnostics and innovative methods of management, including a wider range of treatment options, have resulted in a reduction in co-morbidities associated with HH with improved quality of life and long-term outcomes.
Hyperinsulinemic Hypoglycemia – The Molecular Mechanisms
TL;DR: In older children and adult’s insulinoma, non-insulinoma pancreatogenous hypoglycemia syndrome and post bariatric surgery are recognized causes of HH.
Use of Long-Acting Somatostatin Analogue (Lanreotide) in an Adolescent with Diazoxide-Responsive Congenital Hyperinsulinism and Its Psychological Impact
Pratik Shah,Sofia Rahman,Sharon McElroy,Clare Gilbert,Kate Morgan,Louise Hinchey,Senthil Senniappan,Hannah Levy,Rakesh Amin,Khalid Hussain +9 more
TL;DR: The first case on the use of lanreotide in an adolescent girl with diazoxide-responsive CHI with significant improvement of quality of life is reported, and Clinically significant improvements in the self-reported Paediatric Quality of Life questionnaire and Strengths and Difficulties Questionnaire were reported after 1 year on Lanreotide.
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