Sofia Otaru
University of Helsinki
7 Papers
Sofia Otaru is an academic researcher from University of Helsinki. The author has contributed to research in topics: Chemistry & Tetrazine. The author has an hindex of 2, co-authored 3 publications.
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Papers
Radiolabeled Molecular Imaging Probes for the In Vivo Evaluation of Cellulose Nanocrystals for Biomedical Applications
Surachet Imlimthan,Sofia Otaru,Outi Keinänen,Alexandra Maria Rebelo Correia,Kalle Lintinen,Hélder A. Santos,Anu J. Airaksinen,Mauri A. Kostiainen,Mirkka Sarparanta +8 more
TL;DR: The developed CNC imaging probes can be used to obtain information with noninvasive imaging on the behavior in vivo to guide structural optimization for targeted delivery of diagnostic and therapeutic agents to tumors.
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Development of [18F]AmBF3 Tetrazine for Radiolabeling of Peptides: Preclinical Evaluation and PET Imaging of [18F]AmBF3-PEG7-Tyr3-Octreotide in an AR42J Pancreatic Carcinoma Model
Sofia Otaru,Andreas Paulus,Surachet Imlimthan,Iida Kuurne,Helena E. Virtanen,Heidi Liljenbäck,Tuula Tolvanen,Tatsiana Auchynnikava,Anne Roivainen,K. Helariutta,Mirkka Sarparanta,Anu J. Airaksinen +11 more
TL;DR: The novel AmBF3-Tz demonstrated that it offers potential as a prosthetic group for rapid radiolabeling of biomolecules in mild conditions using bioorthogonal chemistry.
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Evaluation of Organo [18F]Fluorosilicon Tetrazine as a Prosthetic Group for the Synthesis of PET Radiotracers
Sofia Otaru,Surachet Imlimthan,Mirkka Sarparanta,Kerttuli Helariutta,Kristiina Wähälä,Anu J. Airaksinen +5 more
TL;DR: A milder and efficient in vitro and in vivo labeling method for trans-cyclooctene (TCO) functionalized proteins is developed through the bioorthogonal inverse-electron demand Diels-Alder (IEDDA) reaction with fluorine-18 radiolabeled tetrazine ([18F]SiFA-Tz).
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Radiolabelling of peptides with tetrazine ligation based on the inverse electron-demand Diels–Alder reaction: rapid, catalyst-free and mild conversion of 1,4-dihydropyridazines to pyridazines
Sofia Otaru,Tatu Martinmäki,Iida Kuurne,Andreas Paulus,K. Helariutta,Mirkka Sarparanta,Anu J. Airaksinen +6 more
TL;DR: This finding offers a straightforward method for conversion of the metastable DHPs from the IEDDA-based tetrazine ligation to stable, oxidized pyridazines, especially suitable for applications requiring rapid conversion.
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