Sofia N. Moraes
8 Papers
1 Citations
Sofia N. Moraes is an academic researcher. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 3, co-authored 6 publications.
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Papers
Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors
Seyed Arad Moghadasi,Emmanuel Heilmann,Ahmed Magdy Khalil,Christina Nnabuife,Fiona L. Kearns,Chengjin Ye,Sofia N. Moraes,Francesco Costacurta,Morgan A. Esler,Hideki Aihara,Dorothee von Laer,Luis Martinez-Sobrido,Timothy Palzkill,Rommie E. Amaro,Reuben S. Harris +14 more
TL;DR: In this article , the authors investigate the susceptibility of natural variants of the main protease [Mpro; 3C-like protease (3CLpro)] of SARS-CoV-2 to protease inhibitors.
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Ancestral APOBEC3B Nuclear Localization Is Maintained in Humans and Apes and Altered in Most Other Old World Primate Species
Ashley Auerbach,Jordan T. Becker,Sofia N. Moraes,Seyed Arad Moghadasi,Jolene M. Duda,Daniel J. Salamango,Reuben S. Harris +6 more
TL;DR: In this article , the authors combine evolutionary, molecular, and cell biology approaches to address whether nuclear localization is a conserved feature of APOBEC3B in primates, and they show that the ancestral nuclear localization was maintained in present-day human and ape enzymes, but not conserved in other nonhuman primates.
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Cellular assays for dynamic quantification of deubiquitinase activity and inhibition.
Seyed Arad Moghadasi,Sofia N. Moraes,Reuben S. Harris +2 more
TL;DR: The utility of a two-color flow cytometry-based assay that allows for sensitive quantification of DUB activity and inhibition in living cells for studying DUB biology in a cellular context with potential to aid in inhibitor discovery and development is demonstrated.
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Human cytomegalovirus mediates APOBEC3B relocalization early during infection through a ribonucleotide reductase-independent mechanism
Elisa Fanunza,Adam Z. Cheng,Ashley Auerbach,Bojana Stefanovska,Sofia N. Moraes,James R. Lokensgard,Matteo Biolatti,Valentina Dell'Oste,Craig J. Bierle,Wade A. Bresnahan,Reuben S. Harris +10 more
TL;DR: In this article , it was shown that HCMV infection causes the antiviral factor, APOBEC3B, to relocalize from the nuclear compartment to the cytoplasm.
Molecular differences in APOBEC3 counteraction by primate herpesviruses reveal an evolutionary link between the genesis of APOBEC3B and novel viral ribonucleotide reductase function
Sofia N. Moraes,Jordan T. Becker,Seyed Arad Moghadasi,Nadine M. Shaban,Ashley Auerbach,Adam Z. Cheng,Reuben S. Harris +6 more
TL;DR: The results combine to indicate that the genesis of A3B at a critical branchpoint in primate evolution may have been a driving force in selecting herpesviruses with an expanded RNR functionality through counteraction of this antiviral enzyme.
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