Sofia Lövestam
Laboratory of Molecular Biology
16 Papers
Sofia Lövestam is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Chemistry & Biology. The author has an hindex of 2, co-authored 4 publications.
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Papers
Cryo-EM structures of amyloid-β 42 filaments from human brains
Yang Yang,Diana Arseni,Wenjuan Zhang,Melissa C. Huang,Sofia Lövestam,Manuel Schweighauser,Abhay Kotecha,Alexey G. Murzin,Sew Peak‐Chew,Jennifer A. Macdonald,Isabelle Lavenir,Holly J. Garringer,Ellen Gelpi,Kathy Newell,Gabor G. Kovacs,R. Vidal,Bernardino Ghetti,Benjamin Ryskeldi-Falcon,Sjors H.W. Scheres,Michel Goedert +19 more
TL;DR: Cryo–electron microscopy structures of Aβ42 filament structures from human brains are reported, identifying two types of related S-shaped filaments, each consisting of two identical protofilaments, which will inform the development of better in vitro and animal models, inhibitors of A β42 assembly, and imaging agents with increased specificity and sensitivity.
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Seeded assembly in vitro does not replicate the structures of α-synuclein filaments from multiple system atrophy.
Sofia Lövestam,Manuel Schweighauser,Tomoyasu Matsubara,Shigeo Murayama,Taisuke Tomita,Takashi Ando,Kazuko Hasegawa,Mari Yoshida,Airi Tarutani,Airi Tarutani,Masato Hasegawa,Michel Goedert,Sjors H.W. Scheres +12 more
TL;DR: In this article, the atomic structures of α-synuclein filaments from the putamen of five individuals with MSA were determined and the structures of the seeded assemblies were found to differ from those of the seeds, suggesting that additional, as yet unknown, factors play a role in the propagation of seeds.
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Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains
Yang Yang,Wenjuan Zhang,Alexey G. Murzin,Manuel Schweighauser,Melissa Huang,Sofia Lövestam,Sew Peak‐Chew,Takashi Saito,Takaomi C. Saido,Jennifer A. Macdonald,Isabelle Lavenir,Bernardino Ghetti,Caroline Graff,Amit Kumar,Agneta Nordberg,Michel Goedert,Sjors H.W. Scheres +16 more
TL;DR: In this paper , high-resolution cryo-EM structures of Aβ filaments from the frontal cortex of a previously described case (AβPParc1) with the Arctic mutation were reported.
New SNCA mutation and structures of α-synuclein filaments from juvenile-onset synucleinopathy
Yang Yang,Holly J. Garringer,Yang Shi,Sofia Lövestam,Xianjun Zhang,Abhay Kotecha,Mehtap Bacioglu,Atsuo Koto,Masaki Takao,Maria Grazia Spillantini,Bernardino Ghetti,R. Vidal,Alexey G. Murzin,Sjors H.W. Scheres,Michel Goedert +14 more
TL;DR: A 21-nucleotide duplication in one allele of SNCA was identified in a previously described disease with abundant α-synuclein inclusions that was now called juvenile-onset synucleinopathy (JOS), resulting in a protein of 147 amino acids as discussed by the authors .
Data-driven regularisation lowers the size barrier of cryo-EM structure determination
Dari Kimanius,Kiarash Jamali,Max E Wilkinson,Sofia Lövestam,Vaithish Velazhahan,Takanori Nakane,Sjors H.W. Scheres +6 more
TL;DR: The reconstruction of a protein-nucleic acid complex with a molecular weight of 40 kDa illustrates that regularisation through denoising will expand the applicability of cryo-EM structure determination for a wide range of biological macromolecules.
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