Sofia Jürgensen
Federal University of Rio de Janeiro
10 Papers
108 Citations
Sofia Jürgensen is an academic researcher from Federal University of Rio de Janeiro. The author has contributed to research in topics: Biology & Synapse. The author has an hindex of 10, co-authored 10 publications. Previous affiliations of Sofia Jürgensen include Universidade Federal de Santa Catarina & Albert Einstein College of Medicine.
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Papers
Activation of D1/D5 Dopamine Receptors Protects Neurons from Synapse Dysfunction Induced by Amyloid-β Oligomers
Sofia Jürgensen,Leandro Leite Antonio,Gabriela E.A. Mussi,Jordano Brito-Moreira,Theresa R. Bomfim,Fernanda G. De Felice,Emilio R. Garrido-Sanabria,Esper A. Cavalheiro,Sergio T. Ferreira +8 more
TL;DR: It is shown that SKF81297, a selective D1/D5 receptor agonist, prevented the reduction in surface levels of AMPA and NMDA receptors induced by AβOs in hippocampal neurons in culture, and suggest that D1-D5 receptors may be relevant targets for development of novel pharmacological approaches to prevent synapse failure in AD.
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Amyloid-beta oligomers increase the localization of prion protein at the cell surface
Fabiana A. Caetano,Fabiana A. Caetano,Flavio H. Beraldo,Glaucia N. M. Hajj,André Luiz Sena Guimarães,Sofia Jürgensen,Ana Paula Wasilewska-Sampaio,Pedro H. F. Hirata,Ivana A. Souza,Ivana A. Souza,Cleiton F. Machado,Daisy Y.L. Wong,Fernanda G. De Felice,Sergio T. Ferreira,Vania F. Prado,R. Jane Rylett,Vilma R. Martins,Marco A. M. Prado +17 more
TL;DR: In Alzheimer's disease, the amyloid-β peptide (Aβ) interacts with distinct proteins at the cell surface to interfere with synaptic communication, as might be expected if Aβ oligomers use PrPC as a receptor as mentioned in this paper.
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Selective Dysregulation of Hippocampal Inhibition in the Mouse Lacking Autism Candidate Gene CNTNAP2
TL;DR: It is reported that synaptic inhibition specifically onto the perisomatic compartment of CA1 pyramidal cells is impaired, whereas dendritic inhibition and excitatory transmission remain basically unchanged in Cntnap2−/− mice.
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Nicotinic Receptors, Amyloid-β, and Synaptic Failure in Alzheimer’s Disease
TL;DR: In this paper, the role of nicotinic receptors in synaptic plasticity, molecular interactions of Aβ with nAChRs, and how Aβ-induced dysregulation of receptor function may underlie synaptic failure in Alzheimer's disease was examined.
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Lack of galectin-3 speeds Wallerian degeneration by altering TLR and pro-inflammatory cytokine expressions in injured sciatic nerve.
Bruno Siqueira Mietto,Sofia Jürgensen,Lucineia Alves,Cyntia Pecli,Marcelo Sampaio Narciso,Iranaia Assunção-Miranda,Déa Maria Serra Villa-Verde,Flavia Regina Souza Lima,João R. L. Menezes,Claudia F. Benjamim,Marcelo T. Bozza,Ana Maria Blanco Martinez +11 more
TL;DR: Data indicate that the lack of Gal‐3 results in an augmented inflammatory profile that involves the TLR–cytokine pathway, and increases the phagocytic capacity of Schwann cells and macrophages, which ultimately contributes to speeding the course of WD.
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