Sofia De Marco
University of Milano-Bicocca
15 Papers
23 Citations
Sofia De Marco is an academic researcher from University of Milano-Bicocca. The author has contributed to research in topics: Clear cell renal cell carcinoma & Extracellular matrix. The author has an hindex of 5, co-authored 7 publications.
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Papers
The glucose and lipid metabolism reprogramming is grade-dependent in clear cell renal cell carcinoma primary cultures and is targetable to modulate cell viability and proliferation.
Cristina Bianchi,C Meregalli,Silvia Bombelli,Vitalba Di Stefano,Francesco Salerno,Barbara Torsello,Sofia De Marco,Giorgio Bovo,Ingrid Cifola,Eleonora Mangano,Cristina Battaglia,Guido Strada,Giuseppe Lucarelli,Robert H. Weiss,Roberto A. Perego +14 more
TL;DR: The data indicate that in ccRCC the Warburg effect is a grade-dependent feature, and fatty acid oxidation can be activated for different grade- dependent metabolic needs.
36-kDa Annexin A3 Isoform Negatively Modulates Lipid Storage in Clear Cell Renal Cell Carcinoma Cells
Silvia Bombelli,Barbara Torsello,Sofia De Marco,Giuseppe Lucarelli,Ingrid Cifola,C Grasselli,Guido Strada,Giorgio Bovo,Roberto A. Perego,Cristina Bianchi +9 more
TL;DR: The subcellular distribution of AnxA3 in the cellular endocytic compartment suggests its involvement in modulation of vesicular trafficking and might serve as a putative mechanism of lipid storage regulation in ccRCC cells, opening novel translational outcomes.
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The cross‐talk between Abl2 tyrosine kinase and TGFβ1 signalling modulates the invasion of clear cell Renal Cell Carcinoma cells
Sofia De Marco,Barbara Torsello,Emanuela Minutiello,I. Morabito,Chiara Grasselli,Silvia Bombelli,Nicolas Zucchini,Giuseppe Lucarelli,Guido Strada,Roberto A. Perego,Cristina Bianchi +10 more
TL;DR: The authors found that TGFβ1/Smad signalling is more activated in high versus low grade Renal Cell Carcinoma (ccRCC) and inversely correlates with Abl2 tyrosine kinase protein expression.
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Major Action of Endogenous Lysyl Oxidase in Clear Cell Renal Cell Carcinoma Progression and Collagen Stiffness Revealed by Primary Cell Cultures.
Vitalba Di Stefano,Barbara Torsello,Cristina Bianchi,Ingrid Cifola,Eleonora Mangano,Giorgio Bovo,Valeria Cassina,Sofia De Marco,Roberta Corti,C Meregalli,Silvia Bombelli,P Viganò,Cristina Battaglia,Cristina Battaglia,Guido Strada,Roberto A. Perego +15 more
TL;DR: It is found that endogenous LOX is overexpressed in ccRCC, is involved in a positive-regulative loop with HIF-1α, and has a major action onccRCC progression through cellular adhesion, migration, and collagen matrix stiffness increment; however, the oncosuppressive action of Lox-PP was not found to prevail.
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Arg tyrosine kinase modulates TGF-β1 production in human renal tubular cells under high-glucose conditions.
Barbara Torsello,Cristina Bianchi,C Meregalli,Vitalba Di Stefano,Lara Invernizzi,Sofia De Marco,Giorgio Bovo,Rinaldo Brivio,Guido Strada,Silvia Bombelli,Roberto A. Perego +10 more
TL;DR: The downregulation of Arg kinase, induced in human primary tubular cell cultures by incubation in a high glucose concentration, is specifically involved in TGF-β1 overproduction that activates fibroblasts.
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