Sofia Casares
Walter Reed Army Institute of Research
24 Papers
109 Citations
Sofia Casares is an academic researcher from Walter Reed Army Institute of Research. The author has contributed to research in topics: Immune system & Humanized mouse. The author has an hindex of 12, co-authored 24 publications. Previous affiliations of Sofia Casares include Uniformed Services University of the Health Sciences & Naval Medical Research Center.
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Papers
Immune evasion by malaria parasites: a challenge for vaccine development.
Sofia Casares,Thomas L. Richie +1 more
TL;DR: The main mechanisms of immune evasion used by malaria parasites are reviewed and the implications for malaria vaccine development are discussed.
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Humanized HLA-DR4.RagKO.IL2RγcKO.NOD (DRAG) mice sustain the complex vertebrate life cycle of Plasmodium falciparum malaria
Wathsala Wijayalath,Sai Majji,Eileen Villasante,Teodor D. Brumeanu,Thomas L. Richie,Sofia Casares,Sofia Casares +6 more
TL;DR: DRAG mice represent the first human-immune-system humanized mouse model that sustains the complex vertebrate life cycle of P. falciparum parasites and may help deciphering immune correlates of protection and to identify protective malaria antigens.
Double Negative (CD3+4-8-) TCRαβ Splenic Cells from Young NOD Mice Provide Long-Lasting Protection against Type 1 Diabetes
Beverly Duncan,Cristina Nazarov–Stoica,Jacqueline Surls,Margaret Kehl,Constantin A. Bona,Sofia Casares,Sofia Casares,Teodor-D. Brumeanu +7 more
TL;DR: These findings delineate a new T regulatory component in autoimmune diabetes apart from that of NKT and CD4+CD25high Foxp3+T-regulatory cells and could be potentially manipulated towards the development of autologous cell therapies in autoimmune Diabetes.
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Differential effect of HLA class-I versus class-II transgenes on human T and B cell reconstitution and function in NRG mice
Sai Majji,Wathsala Wijayalath,Soumya Shashikumar,Luis Pow-Sang,Eileen Villasante,Teodor D. Brumeanu,Sofia Casares,Sofia Casares +7 more
TL;DR: The results indicated a multifactorial effect of the HLA-DR4 transgene on development and function of human CD4 T cells, antigen-specific human CD8 T Cells, and immunoglobulin class switching.
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Differential effect of CD4+Foxp3+ T-regulatory cells on the B and T helper cell responses to influenza virus vaccination.
Jacqueline Surls,Cristina Nazarov-Stoica,Margaret Kehl,Sofia Casares,Sofia Casares,Teodor-D. Brumeanu +5 more
TL;DR: It is found that immunization of BALB/c mice with a prototype of UV-inactivated influenza PR8/A/34 virus vaccine expanded the CD4(+)Foxp3(+) T-reg pool and fostered the development of virus-specific CD4-specific T-Reg cells.
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