Sobhan Roy
University of Chicago
21 Papers
37 Citations
Sobhan Roy is an academic researcher from University of Chicago. The author has contributed to research in topics: T-cell receptor & Antheraea mylitta. The author has an hindex of 10, co-authored 18 publications. Previous affiliations of Sobhan Roy include Indian Institute of Technology Kharagpur.
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Papers
MAIT cells are imprinted by the microbiota in early life and promote tissue repair
Michael G. Constantinides,Verena M. Link,Samira Tamoutounour,Andrea C. Wong,P. Juliana Perez-Chaparro,Seong-Ji Han,Y. Erin Chen,Kelin Li,Sepideh Farhat,Antonin Weckel,Siddharth R. Krishnamurthy,Ivan Vujkovic-Cvijin,Jonathan L. Linehan,Nicolas Bouladoux,E. Dean Merrill,Sobhan Roy,Daniel J. Cua,Erin J. Adams,Avinash Bhandoola,Tiffany C. Scharschmidt,Jeffrey Aubé,Michael A. Fischbach,Yasmine Belkaid +22 more
TL;DR: How the microbiota can direct immune cell development and subsequent function at mucosal sites by secreting compounds that act like self-antigens is highlighted by highlighting how the bacteria and fungi can direct tissue repair functions by promoting the maturation and homeostasis of the immune system.
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CD1c tetramers detect ex vivo T cell responses to processed phosphomycoketide antigens
Dalam Ly,Anne Kasmar,Tan Yun Cheng,Annemieke de Jong,Shouxiong Huang,Sobhan Roy,Apoorva Bhatt,Ruben P. van Summeren,John D. Altman,William R. Jacobs,Erin J. Adams,Adriaan J. Minnaard,Steven A. Porcelli,D. Branch Moody +13 more
TL;DR: CD1c tetramers loaded with a phospholipid antigen from M. tuberculosis are recognized by human T cells and are distinguished from normal T cells by the immune system.
Molecular Analysis of Lipid-Reactive Vδ1 γδ T Cells Identified by CD1c Tetramers.
Sobhan Roy,Dalam Ly,Dalam Ly,Caitlin D. Castro,Nan-Sheng Li,Andrew J. Hawk,John D. Altman,Stephen C. Meredith,Joseph A. Piccirilli,D. Branch Moody,Erin J. Adams +10 more
TL;DR: Dissection of TCR interactions with CD1c carrying foreign Ags, permissive ligands, and nonpermissive lipid ligands clarifies the molecular basis of the frequently observed but poorly understood phenomenon of mixed self- and foreign Ag reactivity in the CD1 system.
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Generation and molecular recognition of melanoma-associated antigen-specific human γδ T cells
Patricia M. Benveniste,Sobhan Roy,Munehide Nakatsugawa,Edward L. Y. Chen,Linh T. Nguyen,Douglas G. Millar,Pamela S. Ohashi,Naoto Hirano,Naoto Hirano,Erin J. Adams,Juan Carlos Zúñiga-Pflücker,Juan Carlos Zúñiga-Pflücker,Juan Carlos Zúñiga-Pflücker +12 more
TL;DR: The findings reveal that classical MHC-restricted human γδ TCRs exist in the periphery and have the potential to be used in developing of new TCR-based immunotherapeutic approaches.
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Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by αβ T cells
Sobhan Roy,Dalam Ly,Nan-Sheng Li,John D. Altman,Joseph A. Piccirilli,D. Branch Moody,Erin J. Adams +6 more
TL;DR: This study shows how a subset of αβ T cells targets M. tuberculosis lipid antigens that are presented by the MHC molecule CD1c, and demonstrates that the α β T-cell response toCD1c lipid presentation is diverse and adaptable.
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